ID   BF24
AC   CVCL_X687
SY   BF-24
DR   BEI_Resources; ARP-1296
DR   cancercelllines; CVCL_X687
DR   Wikidata; Q54796173
RX   PubMed=2789383;
CC   Population: Japanese.
CC   Characteristics: Contains stably integrated, silent copies of the HIV-1 LTR promoter linked to the CAT gene (PubMed=2789383).
CC   Virology: Sensitive indicator cell line for HIV-1 Tat. When infected by HIV-1, BF24 produces high levels of chloramphenicol acetyl transferase (CAT) (BEI_Resources=ARP-1296).
CC   Sequence variation: Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P62577; Escherichia coli cat.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0006 ! THP-1
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 19-12-24; Version: 18
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RX   PubMed=2789383; DOI=10.1073/pnas.86.18.7200; PMCID=PMC298024;
RA   Schwartz S., Felber B.K., Fenyo E.-M., Pavlakis G.N.;
RT   "Rapidly and slowly replicating human immunodeficiency virus type 1
RT   isolates can be distinguished according to target-cell tropism in
RT   T-cell and monocyte cell lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:7200-7203(1989).
//