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Cellosaurus THP1-Xblue (CVCL_X582)

[Text version]
Cell line name THP1-Xblue
Accession CVCL_X582
Resource Identification Initiative To cite this cell line use: THP1-Xblue (RRID:CVCL_X582)
Comments Population: Japanese.
Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of a NF-KappaB/AP-1 promoter.
Transfected with: HGNC; 439; ALPP.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
CVCL_X583 (THP1-Xblue-CD14)CVCL_X586 (THP1-XBlue-defMyD)CVCL_X584 (THP1-Xblue-MD2-CD14)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages https://www.invivogen.com/thp1-xblue-cell

PubMed=25130606; DOI=10.1016/j.intimp.2014.08.002
Chanput W., Mes J.J., Wichers H.J.
THP-1 cell line: an in vitro cell model for immune modulation approach.
Int. Immunopharmacol. 23:37-45(2014)

Cell line databases/resources cancercelllines; CVCL_X582
Encyclopedic resources Wikidata; Q54972375
Entry history
Entry creation05-Sep-2014
Last entry update05-Oct-2023
Version number15