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Cellosaurus THP1-XBlue-CD14 (CVCL_X583)

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Cell line name THP1-XBlue-CD14
Accession CVCL_X583
Resource Identification Initiative To cite this cell line use: THP1-XBlue-CD14 (RRID:CVCL_X583)
Comments Population: Japanese.
Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of a NF-KappaB/AP-1 promoter (InvivoGen=thpx-cd14sp).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:439; ALPP.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:1628; CD14.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_X582 (THP1-XBlue)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages Provider; InvivoGen; thpx-cd14sp; https://web.archive.org/web/20180324004727/http://www.invivogen.com/thp1-xblue-cd14-cell
Publications

PubMed=25130606; DOI=10.1016/j.intimp.2014.08.002
Wasaporn Chanput, Jurriaan J. Mes, Harry J. Wichers;
THP-1 cell line: an in vitro cell model for immune modulation approach.
Int. Immunopharmacol. 23:37-45(2014)

Cross-references
Cell line collections (Providers) InvivoGen; thpx-cd14sp - Discontinued
Cell line databases/resources cancercelllines; CVCL_X583
Encyclopedic resources Wikidata; Q54972376
Entry history
Entry creation05-Sep-2014
Last entry update14-Aug-2025
Version number19