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Cellosaurus THP-1 K5 Y/A (CVCL_F1K7)

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Cell line name THP-1 K5 Y/A
Accession CVCL_F1K7
Resource Identification Initiative To cite this cell line use: THP-1 K5 Y/A (RRID:CVCL_F1K7)
Comments Population: Japanese.
Genetic integration: Method=Transduction; Gene=UniProtKB; P90489; Human herpesvirus 8 type P (isolate GK18) E3 ubiquitin-protein ligase MIR2 (K5) (Note=With p.Tyr156Ala).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

PubMed=21490960; DOI=10.1371/journal.ppat.1001331; PMCID=PMC3072377
Roshan Karki, Sabine Martha Lang, Robert E. Means;
The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation.
PLoS Pathog. 7:e1001331.1-e1001331.15(2011)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1