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Cellosaurus THP1 ST-PEAK3 (CVCL_C0QY)

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Cell line name THP1 ST-PEAK3
Accession CVCL_C0QY
Resource Identification Initiative To cite this cell line use: THP1 ST-PEAK3 (RRID:CVCL_C0QY)
Comments Population: Japanese.
Characteristics: Transfected with a pSBbi-PuroR-ST-PEAK3 that contains a N-terminally Strep-tagged PEAK3.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:24793; PEAK3 (Note=With a N-terminal Strep tag).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

PubMed=34944965; DOI=10.3390/cancers13246344; PMCID=PMC8699254
Youcef Ounoughene, Elise Fourgous, Yvan Boublik, Estelle Saland, Nathan Guiraud, Christian Recher, Serge Urbach, Philippe Fort, Jean-Emmanuel Sarry, Didier Fesquet, Serge Roche;
SHED-dependent oncogenic signaling of the PEAK3 pseudo-kinase.
Cancers (Basel) 13:6344.1-6344.18(2021)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0QY
Encyclopedic resources Wikidata; Q112930477
Proteomic databases PRIDE; PXD029417
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number8