ID   THP1 ST-PEAK3
AC   CVCL_C0QY
DR   cancercelllines; CVCL_C0QY
DR   PRIDE; PXD029417
DR   Wikidata; Q112930477
RX   PubMed=34944965;
CC   Population: Japanese.
CC   Characteristics: Transfected with a pSBbi-PuroR-ST-PEAK3 that contains a N-terminally Strep-tagged PEAK3.
CC   Sequence variation: Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; 24793; PEAK3 (Note=With a N-terminal Strep tag).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; S.alboniger pac (PuroR).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0006 ! THP-1
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 23-06-22; Last updated: 10-09-24; Version: 6
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RX   PubMed=34944965; DOI=10.3390/cancers13246344; PMCID=PMC8699254;
RA   Ounoughene Y., Fourgous E., Boublik Y., Saland E., Guiraud N.,
RA   Recher C., Urbach S., Fort P., Sarry J.-E., Fesquet D., Roche S.;
RT   "SHED-dependent oncogenic signaling of the PEAK3 pseudo-kinase.";
RL   Cancers (Basel) 13:6344.1-6344.18(2021).
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