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Cellosaurus CellSensor TNFalpha-bla THP-1 (CVCL_KS30)

[Text version]
Cell line name CellSensor TNFalpha-bla THP-1
Synonyms TNFalpha-bla THP-1
Accession CVCL_KS30
Resource Identification Initiative To cite this cell line use: CellSensor TNFalpha-bla THP-1 (RRID:CVCL_KS30)
Comments Population: Japanese.
Characteristics: Transfected with a plasmid containing a beta-lactamase reporter gene which has been randomly integrated in the genome of THP-1 and which has been selected for TNFalpha-responsiveness.
Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transfection; Gene=UniProtKB; P62593; Escherichia coli beta-lactamase bla (Note=With p.Met1_Phe22del, p.Ala23Met, p.Val82Ile and p.Met184Val).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages Provider; Thermo Fisher; K1672B; https://www.thermofisher.com/order/catalog/product/K1672B
Cross-references
Cell line databases/resources cancercelllines; CVCL_KS30
Encyclopedic resources Wikidata; Q54809240
Entry history
Entry creation22-Aug-2017
Last entry update14-Aug-2025
Version number16