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Cellosaurus U-87MG ATCC (CVCL_0022)

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Cell line name U-87MG ATCC
Synonyms U-87MG; U-87 MG; U87 MG; U-87-MG; U87-MG; U87MG; U-87; U87; 87 MG; 87MG
Accession CVCL_0022
Resource Identification Initiative To cite this cell line use: U-87MG ATCC (RRID:CVCL_0022)
Comments Problematic cell line: Misidentified. This cell line is not the original glioblastoma cell line established in 1968 at the University of Uppsala. As described in PubMed=27582061 it is most probably also a glioblastoma cell line but whose origin is unknow. See U-87MG Uppsala (Cellosaurus=CVCL_GP63) for the original U-87MG cell line.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Part of: Human Protein Atlas, Cell Atlas panel.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00535.
Population: Caucasian.
Doubling time: 39 hours (PubMed=9842975); 72 hours (PubMed=25984343); ~34 hours (PBCF).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Proteomics; HLA class I peptidome.
Omics: Proteomics; Quantitative.
Omics: Proteomics; Subcellular; Cell surface.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Sequence variations
  • Mutation; HGNC; HGNC:5382; IDH1; None_reported; -; Zygosity=- (PubMed=19435942).
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (Cosmic-CLP=687590; DepMap=ACH-000075).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=9090379; Cosmic-CLP=687590; DepMap=ACH-000075).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
  • Mutation; HGNC; HGNC:11998; TP53; None_reported; -; Zygosity=- (Cosmic-CLP=687590; DepMap=ACH-000075).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*02:01,02:01
HLA-BB*44:02,44:02
HLA-CC*05:01,05:01
Class II
HLA-DQDQA1*01:02,01:02
DQB1*06:02,06:02
HLA-DRDRB1*15:01,13:07

Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*44:02,44:02
HLA-CC*05:01,05:01

Source: PubMed=27412690
Class I
HLA-AA*02:01:01
HLA-BB*44:02
HLA-CC*05:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.69
Native American0
East Asian, North3.92
East Asian, South0
South Asian0
European, North72.18
European, South23.21
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_D1RF (Abcam U-87MG ABCA1 KO)CVCL_D1RG (Abcam U-87MG ABL1 KO)CVCL_D1RH (Abcam U-87MG ADAM10 KO)
CVCL_D1RI (Abcam U-87MG ADRB3 KO)CVCL_D1RJ (Abcam U-87MG AKR1C1 KO)CVCL_D1RK (Abcam U-87MG ALDH1A1 KO)
CVCL_D1RL (Abcam U-87MG APP KO)CVCL_D1RM (Abcam U-87MG ASNS KO)CVCL_D1RN (Abcam U-87MG ASS1 KO)
CVCL_D1RP (Abcam U-87MG ATP1A3 KO)CVCL_D1RQ (Abcam U-87MG BACE2 KO)CVCL_D1RR (Abcam U-87MG BEST1 KO)
CVCL_D1RS (Abcam U-87MG BIN1 KO)CVCL_D1RT (Abcam U-87MG CACNA2D1 KO)CVCL_D1RU (Abcam U-87MG CAV1 KO)
CVCL_D1RV (Abcam U-87MG CD82 KO)CVCL_D1RW (Abcam U-87MG CHI3L1 KO)CVCL_D1RX (Abcam U-87MG CHRM3 KO)
CVCL_D1RY (Abcam U-87MG CHRNA5 KO)CVCL_D1RZ (Abcam U-87MG CNTNAP1 KO)CVCL_D1S0 (Abcam U-87MG CSF1 KO)
CVCL_D1S1 (Abcam U-87MG CST3 KO)CVCL_D1S2 (Abcam U-87MG CTSD KO)CVCL_D1S3 (Abcam U-87MG CYP1B1 KO)
CVCL_D1S4 (Abcam U-87MG DCX KO)CVCL_D1S5 (Abcam U-87MG DLG4 KO)CVCL_D1S6 (Abcam U-87MG DRD1 KO)
CVCL_D1S7 (Abcam U-87MG DYRK1A KO)CVCL_D1S8 (Abcam U-87MG ECE1 KO)CVCL_D1S9 (Abcam U-87MG EGFR KO)
CVCL_D1SA (Abcam U-87MG ELAVL3 KO)CVCL_D1SB (Abcam U-87MG ELAVL4 KO)CVCL_D1SC (Abcam U-87MG ENPP2 KO)
CVCL_D1SD (Abcam U-87MG ERN1 KO)CVCL_D1SE (Abcam U-87MG FGFR1 KO)CVCL_D1SF (Abcam U-87MG FLT1 KO)
CVCL_D1SG (Abcam U-87MG FMR1 KO)CVCL_D1SH (Abcam U-87MG FN1 KO)CVCL_D1SI (Abcam U-87MG FOS KO)
CVCL_D1SJ (Abcam U-87MG FOXA2 KO)CVCL_D1SK (Abcam U-87MG FOXC2 KO)CVCL_D1SL (Abcam U-87MG G3BP1 KO)
CVCL_D1SM (Abcam U-87MG GABBR1 KO)CVCL_D1SN (Abcam U-87MG GABRA1 KO)CVCL_D1SP (Abcam U-87MG GAD1 KO)
CVCL_D1SQ (Abcam U-87MG GBA KO)CVCL_D1SR (Abcam U-87MG GFAP KO)CVCL_D1SS (Abcam U-87MG GJA1 KO)
CVCL_D1ST (Abcam U-87MG GLUL KO)CVCL_D1SU (Abcam U-87MG GRIA1 KO)CVCL_D1SV (Abcam U-87MG GRIA2 KO)
CVCL_D1SW (Abcam U-87MG GRIA4 KO)CVCL_D1SX (Abcam U-87MG GRIN2A KO)CVCL_D1SY (Abcam U-87MG GRIN2B KO)
CVCL_D1SZ (Abcam U-87MG GRM1 KO)CVCL_D1T0 (Abcam U-87MG GRM3 KO)CVCL_D1T1 (Abcam U-87MG GRM5 KO)
CVCL_D1T2 (Abcam U-87MG GRM7 KO)CVCL_D1T3 (Abcam U-87MG GSK3A KO)CVCL_D1T4 (Abcam U-87MG GSN KO)
CVCL_D1T5 (Abcam U-87MG HTR7 KO)CVCL_D1T6 (Abcam U-87MG HTT KO)CVCL_D1T7 (Abcam U-87MG IDH1 KO)
CVCL_D1T8 (Abcam U-87MG IL13RA2 KO)CVCL_D1T9 (Abcam U-87MG ITPR1 KO)CVCL_D1TA (Abcam U-87MG KCND2 KO)
CVCL_D1TB (Abcam U-87MG KCNJ6 KO)CVCL_D1TC (Abcam U-87MG KEAP1 KO)CVCL_D1TD (Abcam U-87MG L1CAM KO)
CVCL_D1TE (Abcam U-87MG LAMP1 KO)CVCL_D1TF (Abcam U-87MG LAMP2 KO)CVCL_D1TG (Abcam U-87MG LGI1 KO)
CVCL_D1TH (Abcam U-87MG LOXL1 KO)CVCL_D1TI (Abcam U-87MG MAP2 KO)CVCL_B0ZG (Abcam U-87MG MAPT KO)
CVCL_D1TJ (Abcam U-87MG MGLL KO)CVCL_D1TK (Abcam U-87MG MMP3 KO)CVCL_D1TL (Abcam U-87MG MMP9 KO)
CVCL_D1TM (Abcam U-87MG NCAM1 KO)CVCL_D1TN (Abcam U-87MG NCSTN KO)CVCL_D1TP (Abcam U-87MG NEO1 KO)
CVCL_D1TQ (Abcam U-87MG NFE2L2 KO)CVCL_D1TR (Abcam U-87MG NPTX1 KO)CVCL_D1TS (Abcam U-87MG NRP2 KO)
CVCL_D1TT (Abcam U-87MG NTRK2 KO)CVCL_D1TU (Abcam U-87MG NTRK3 KO)CVCL_D1TV (Abcam U-87MG PARK7 KO)
CVCL_D1TW (Abcam U-87MG PDE5A KO)CVCL_D1TX (Abcam U-87MG PEA15 KO)CVCL_D1TY (Abcam U-87MG PLA2G6 KO)
CVCL_D1TZ (Abcam U-87MG PLAUR KO)CVCL_D1U0 (Abcam U-87MG PLXNB2 KO)CVCL_D1U1 (Abcam U-87MG PML KO)
CVCL_D1U2 (Abcam U-87MG PRKCA KO)CVCL_D1U3 (Abcam U-87MG PRKCD KO)CVCL_D1U4 (Abcam U-87MG PRKCG KO)
CVCL_D1U5 (Abcam U-87MG RAB39B KO)CVCL_D1U6 (Abcam U-87MG RAB8A KO)CVCL_D1U7 (Abcam U-87MG ROBO1 KO)
CVCL_D1U8 (Abcam U-87MG RUNx1 KO)CVCL_D1U9 (Abcam U-87MG SCARB2 KO)CVCL_D1UA (Abcam U-87MG SCG2 KO)
CVCL_D1UB (Abcam U-87MG SDHB KO)CVCL_D1UC (Abcam U-87MG SERPINB2 KO)CVCL_D1UD (Abcam U-87MG SERPINE1 KO)
CVCL_D1UE (Abcam U-87MG SFRP1 KO)CVCL_D1UF (Abcam U-87MG SLC2A3 KO)CVCL_D1UG (Abcam U-87MG SLC6A4 KO)
CVCL_D1UH (Abcam U-87MG SLIT2 KO)CVCL_C0BJ (Abcam U-87MG SNCA KO)CVCL_D1UI (Abcam U-87MG SQSTM1 KO)
CVCL_D1UJ (Abcam U-87MG STMN1 KO)CVCL_E4AP (Abcam U-87MG STXBP1 KO)CVCL_D1UK (Abcam U-87MG TBX2 KO)
CVCL_D1UL (Abcam U-87MG TH KO)CVCL_E9DI (Abcam U-87MG TICAM1 KO)CVCL_D1UM (Abcam U-87MG TLR4 KO)
CVCL_D1UN (Abcam U-87MG TNC KO)CVCL_D1UP (Abcam U-87MG TNFAIP3 KO)CVCL_D1UQ (Abcam U-87MG TRPM8 KO)
CVCL_D1UR (Abcam U-87MG TSPO KO)CVCL_D1US (Abcam U-87MG TUBB3 KO)CVCL_D1UT (Abcam U-87MG UBE3A KO)
CVCL_D1UU (Abcam U-87MG UCHL1 KO)CVCL_D1UV (Abcam U-87MG VCAN KO)CVCL_D1UW (Abcam U-87MG VIM KO)
CVCL_D1UX (Abcam U-87MG VLDLR KO)CVCL_D7C9 (Abeomics U87MG GFP)CVCL_D6CV (HyCyte U-87MG KO-hFGL2)
CVCL_D6CW (HyCyte U-87MG KO-hNUPR1)CVCL_D6CX (HyCyte U-87MG KO-hTP53)CVCL_E3IU (HyCyte U-87MG-Luc)
CVCL_C8WL (U-87 MG-EGFP)CVCL_C8WM (U-87 MG-Luc)CVCL_5J15 (U-87 MG-luc2)
CVCL_UR33 (U-87 MG-Luc2)CVCL_UE09 (U-87MG ATCC IDH1 p.R132H)CVCL_C6JA (U-87MG ATCC ECE1 KO)
CVCL_F0QD (U-87MG ATCC HTT KO)CVCL_C3IF (U-87MG-parkin clone 19)CVCL_C3IG (U-87MG-parkin clone 25)
CVCL_C3IE (U-87MG-parkin clone 7)CVCL_VL16 (U-87MG/DDP)CVCL_5J12 (U87 MG-Red-FLuc)
CVCL_X702 (U87-CD4 clone 2)CVCL_C9F7 (U87-MG/Cas9 AAVS1)CVCL_4V16 (U87-MG/Pt)
CVCL_X626 (U87.CD4)CVCL_3428 (U87/DK)CVCL_3429 (U87/WT)
CVCL_A5CL (U87DND)CVCL_E9YD (U87MG-Fluc)CVCL_E9YE (U87MG-Venus-Akaluc)
CVCL_E9YF (U87MG-Venus-Fluc)CVCL_JY78 (U87MG.deltaEGFR)CVCL_JY80 (U87MG.DY1)
CVCL_JY81 (U87MG.DY2)CVCL_JY82 (U87MG.DY3)CVCL_JY83 (U87MG.DY4)
CVCL_JY84 (U87MG.DY5)CVCL_C6IK (U87MG/ALDH1A3-KO.1)CVCL_C6IL (U87MG/CPOX-KO)
CVCL_E1E9 (Ubigene U-87 MG ABCA1 KO)CVCL_E1EA (Ubigene U-87 MG CARD8-AS1 KO)CVCL_E1EB (Ubigene U-87 MG CD9 KO)
CVCL_E1EC (Ubigene U-87 MG DUS4L KO)CVCL_E1ED (Ubigene U-87 MG DYNC2H1 KO)CVCL_E1EE (Ubigene U-87 MG EREG KO)
CVCL_E1EF (Ubigene U-87 MG FAP KO)CVCL_E1EG (Ubigene U-87 MG HMOX1 KO)CVCL_E1EH (Ubigene U-87 MG IDH1 KO)
CVCL_E1EI (Ubigene U-87 MG NF1 KO)CVCL_E1EJ (Ubigene U-87 MG NFE2L2 KO)CVCL_E1EK (Ubigene U-87 MG NFKB1 KO)
CVCL_E1EL (Ubigene U-87 MG RSRP1 KO)CVCL_E1EM (Ubigene U-87 MG SAMD9L KO)CVCL_E1EN (Ubigene U-87 MG SERPINE1 KO)
CVCL_E1EP (Ubigene U-87 MG SIRT3 KO)CVCL_E1EQ (Ubigene U-87 MG SIRT7 KO)CVCL_E1ER (Ubigene U-87 MG SLC7A11 KO)
CVCL_E1ES (Ubigene U-87 MG TRIB3 KO)CVCL_E1ET (Ubigene U-87 MG TSC2 KO)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): AddexBio=C0005002/71; ATCC=HTB-14; CCRID; CLS=300367; Cosmic-CLP=687590; ECACC=89081402; KCLB=30014; PubMed=11416159; PubMed=22570425; PubMed=25877200; PubMed=27582061; Technion Genomics Center

Markers:
AmelogeninX (AddexBio=C0005002/71; CCRID; CLS=300367; ECACC=89081402; PubMed=11416159; PubMed=22570425; PubMed=25877200; PubMed=27582061; Technion Genomics Center)
X,Y (ATCC=HTB-14; Cosmic-CLP=687590; KCLB=30014)
CSF1PO10,11
D1S165615
D2S44110,11
D2S133820,23
D3S135816,17
D5S81811,12
D7S8208,9
D8S117910,11
D10S124814
D12S39118,21
D13S3178,11
D16S53912
D18S5113 (CLS=300367; PubMed=22570425)
13,14 (ATCC=HTB-14; CCRID; PubMed=11416159; PubMed=25877200; Technion Genomics Center)
D19S43315,15.2
D21S1128,32.2
D22S104515,17
FGA18,24
Penta D9,14
Penta E7,14
TH019.3
TPOX8
vWA15,17

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/atcc-htb-14-morphology-and-growth-conditions
Info; ENCODE; -; http://genome.ucsc.edu/ENCODE/protocols/cell/human/U-87_Myers_protocol.pdf
Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=58
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544489
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/u/cell-lines-detail-314.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/U87
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/brain-cancer-xenograft/u87-xenograft-model/
Publications

PubMed=327080; DOI=10.1093/jnci/59.1.221
Jorgen Fogh, Jens M. Fogh, Thomas Orfeo;
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Jorgen Fogh, William C. Wright, James D. Loveless;
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=450131; DOI=10.1038/279797a0
Rufus S. Day 3rd, Chuck H.J. Ziolkowski;
Human brain tumour cell strains with deficient host-cell reactivation of N-methyl-N'-nitro-N-nitrosoguanidine-damaged adenovirus 5.
Nature 279:797-799(1979)

PubMed=22282976; DOI=10.1093/carcin/1.1.21
Rufus S. Day 3rd, Chuck H.J. Ziolkowski, Dominic A. Scudiero, Sharon A. Meyer, Michael R. Mattern;
Human tumor cell strains defective in the repair of alkylation damage.
Carcinogenesis 1:21-32(1980)

PubMed=7459858
Monique Rousset, Alain Zweibaum, Jorgen Fogh;
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=3518877; DOI=10.3109/07357908609038260
Jorgen Fogh;
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=7763724
Motonobu Satoh, Masao Takeuchi;
Cross-contamination of cell lines as revealed by DNA fingerprinting in the IFO animal cell bank.
Res. Commun. Inst. Ferment. 16:18-23(1993)

PubMed=8069455; DOI=10.1007/BF02631450
Ken-ichiro Fukuchi, Mark G. Hearn, Samir S. Deeb, Annette C. Smith, Dang Ngoc Thao, Jun-ichi Miyazaki, Mark Bothwell, George M. Martin;
Activity assays of nine heterogeneous promoters in neural and other cultured cells.
In Vitro Cell. Dev. Biol. Anim. 30:300-305(1994)

PubMed=9090379; DOI=10.1038/ng0497-356
Peter A. Steck, Mark A. Pershouse, Samar A. Jasser, Wai-Kwan Alfred Yung, Huai Lin, Azra Hadi Ligon, Lauren A. Langford, Michelle L. Baumgard, Thomas Hattier, Thaylon Davis, Cheryl Frye, Rong Hu, Bradley Swedlund ...Show all 15 authors... , David H.-F. Teng, Sean V. Tavtigian; Show fewer authors
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
Nat. Genet. 15:356-362(1997)

PubMed=9230885; DOI=10.1093/jnci/89.14.1036
Candelaria Gomez-Manzano, Juan Fueyo, Athanassios P. Kyritsis, Timothy J. McDonnell, Peter A. Steck, Victor Alan Levin, Wai-Kwan Alfred Yung;
Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis.
J. Natl. Cancer Inst. 89:1036-1044(1997)

PubMed=9842975; DOI=10.1002/(SICI)1097-0215(19981218)79:6<640::AID-IJC15>3.0.CO;2-Z
Michael Weller, Johannes Rieger, Cornelia Grimmel, Erwin G. Van Meir, Nicolas De Tribolet, Stanislaw Krajewski, John C. Reed, Andreas von Deimling, Johannes Dichgans;
Predicting chemoresistance in human malignant glioma cells: the role of molecular genetic analyses.
Int. J. Cancer 79:640-644(1998)

PubMed=10074188; DOI=10.1128/JVI.73.4.3338-3350.1999; PMCID=PMC104098
Nathalie Arbour, Genevieve Cote, Claude Lachance, Marc Tardieu, Neil R. Cashman, Pierre J. Talbot;
Acute and persistent infection of human neural cell lines by human coronavirus OC43.
J. Virol. 73:3338-3350(1999)

PubMed=10402232; DOI=10.3892/ijo.15.2.237
Taraneh R. Sharif, Mohammed Sharif;
Overexpression of protein kinase C epsilon in astroglial brain tumor derived cell lines and primary tumor samples.
Int. J. Oncol. 15:237-243(1999)

PubMed=10416987; DOI=10.1111/j.1750-3639.1999.tb00536.x; PMCID=PMC8098486
Nobuaki Ishii, Daniel Maier, Adrian Merlo, Mitsuhiro Tada, Yutaka Sawamura, Annie-Claire Diserens, Erwin G. Van Meir;
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines.
Brain Pathol. 9:469-479(1999)

PubMed=10560660; DOI=10.1097/00005072-199911000-00007
Esther E. Schmidt, Koichi Ichimura, Helena M. Goike, Ahmad Moshref, Lu Liu, Vincent Peter Collins;
Mutational profile of the PTEN gene in primary human astrocytic tumors and cultivated xenografts.
J. Neuropathol. Exp. Neurol. 58:1170-1183(1999)

PubMed=11414198; DOI=10.1007/s004320000207
Harald Lahm, Sabine Andre, Andreas Hoeflich, Jurgen R. Fischer, Bernard Sordat, Herbert Kaltner, Eckhard Wolf, Hans-Joachim Gabius;
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland, Maureen Harrison, Arvind K. Virmani ...Show all 16 authors... , Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11966317; DOI=10.1667/0033-7587(2002)157[0516:LDRHIH]2.0.CO;2
Sudhir Chandna, Bilikere Srinivasa Rao Dwarakanath, Divya Khaitan, T. Lazar Mathew, Viney Jain;
Low-dose radiation hypersensitivity in human tumor cell lines: effects of cell-cell contact and nutritional deprivation.
Radiat. Res. 157:516-525(2002)

PubMed=14614447; DOI=10.1038/sj.onc.1207198
Jorg Wischhusen, Ulrike Naumann, Hiroko Ohgaki, Farzan Rastinejad, Michael Weller;
CP-31398, a novel p53-stabilizing agent, induces p53-dependent and p53-independent glioma cell death.
Oncogene 22:8233-8245(2003)

PubMed=14655754; DOI=10.1111/j.1750-3639.2003.tb00479.x; PMCID=PMC8095903
Oliver Bahr, Johannes Rieger, Frank Duffner, Richard Meyermann, Michael Weller, Wolfgang Wick;
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Brain Pathol. 13:482-494(2003)

PubMed=14961077; DOI=10.1038/sj.onc.1207244
Ying-Lin Wang, Shao-Jun Zhu, Timothy Frances Cloughesy, Linda M. Liau, Paul Salomon Mischel;
p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition.
Oncogene 23:1283-1290(2004)

PubMed=16232199; DOI=10.1111/j.1349-7006.2005.00099.x; PMCID=PMC11159392
Kuniyasu Saigusa, Naoya Hashimoto, Hitoshi Tsuda, Sana Yokoi, Motohiko Maruno, Toshiki Yoshimine, Masaru Aoyagi, Kikuo Ohno, Issei Imoto, Johji Inazawa;
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Cancer Sci. 96:676-683(2005)

PubMed=16697959; DOI=10.1016/j.ccr.2006.03.030
Jeongwu Lee, Svetlana Kotliarova, Yuri Kotliarov, Ai-Guo Li, Qin Su, Nicholas Murray Donin, Sandra Pastorino, Benjamin W. Purow, Neil Christopher, Wei Zhang, John K. Park, Howard Alan Fine;
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines.
Cancer Cell 9:391-403(2006)

PubMed=17595512; DOI=10.1159/000104150
Johannes Rieger, Brigitte Frank, Michael Weller, Wolfgang Wick;
Mechanisms of resistance of human glioma cells to Apo2 ligand/TNF-related apoptosis-inducing ligand.
Cell. Physiol. Biochem. 20:23-34(2007)

PubMed=19365568; DOI=10.1371/journal.pone.0005209; PMCID=PMC2666263
Dorine Arjanne Bax, Suzanne E. Little, Nathalie Gaspar, Lara Perryman, Lynley Marshall, Marta Viana-Pereira, Tania A. Jones, Richard D. Williams, Anita Grigoriadis, Gilles Vassal, Paul Workman, Denise Sheer, Rui Manuel Reis ...Show all 16 authors... , Andrew D.J. Pearson, Darren Hargrave, Chris Jones; Show fewer authors
Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development.
PLoS ONE 4:e5209.1-e5209.9(2009)

PubMed=19435942; DOI=10.1215/15228517-2009-025; PMCID=PMC2743214
Koichi Ichimura, Danita M. Pearson, Sylvia Kocialkowski, L. Magnus Backlund, Raymond Chan, David T.W. Jones, Vincent Peter Collins;
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas.
Neuro-oncol. 11:341-347(2009)

PubMed=20126413; DOI=10.1371/journal.pgen.1000832; PMCID=PMC2813426
Michael James Clark, Nils Homer, Brian D. O'Connor, Zu-Gen Chen, Ascia Eskin, Hane Lee, Barry Merriman, Stanley F. Nelson;
U87MG decoded: the genomic sequence of a cytogenetically aberrant human cancer cell line.
PLoS Genet. 6:e1000832.1-e1000832.16(2010)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa, Jonathan Hinton, Ciara Fahey ...Show all 22 authors... , Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera, Rui Wang, Angela Tam ...Show all 22 authors... , Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20587068; DOI=10.1186/1471-2407-10-339; PMCID=PMC2909207
Hiromichi Nakabayashi, Toshio Yawata, Keiji Shimizu;
Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells.
BMC Cancer 10:339.1-339.9(2010)

PubMed=20593219; DOI=10.1007/s11060-010-0283-9
Michael D. Blough, Desiree C. Beauchamp, Morgan R. Westgate, John J.P. Kelly, J. Gregory Cairncross;
Effect of aberrant p53 function on temozolomide sensitivity of glioma cell lines and brain tumor initiating cells from glioblastoma.
J. Neurooncol. 102:1-7(2011)

PubMed=21406405; DOI=10.1158/0008-5472.CAN-10-3112
Michal Grzmil, Pier Morin Jr., Maria Maddalena Lino, Adrian Merlo, Stephan Frank, Yu-Hua Wang, Gerald Moncayo, Brian Arthur Hemmings;
MAP kinase-interacting kinase 1 regulates SMAD2-dependent TGF-beta signaling pathway in human glioblastoma.
Cancer Res. 71:2392-2402(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy, Manway Liu, Lauren Murray ...Show all 61 authors... , Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22570425; DOI=10.1093/neuonc/nos072; PMCID=PMC3367844
Pierre Bady, Annie-Claire Diserens, Vincent Castella, Stefanie Kalt, Karl Heinimann, Marie-France Hamou, Mauro Delorenzi, Monika E. Hegi;
DNA fingerprinting of glioma cell lines and considerations on similarity measurements.
Neuro-oncol. 14:701-711(2012)

PubMed=23325432; DOI=10.1101/gr.147942.112; PMCID=PMC3589544
Katherine E. Varley, Jason Gertz, Kevin M. Bowling, Stephanie L. Parker, Timothy E. Reddy, Florencia Pauli-Behn, Marie K. Cross, Brian A. Williams, John A. Stamatoyannopoulos, Gregory E. Crawford, Devin Michael Absher, Barbara Jane Wold, Richard M. Myers; Show fewer authors ...Show all 13 authors...
Dynamic DNA methylation across diverse human cell lines and tissues.
Genome Res. 23:555-567(2013)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte, Guo-Zhi Jiang, Jessica Hsiao ...Show all 40 authors... , Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=25894527; DOI=10.1371/journal.pone.0121314; PMCID=PMC4404347
Damaris Bausch-Fluck, Andreas Hofmann, Thomas Bock, Andreas P. Frei, Ferdinando Cerciello, Andrea Jacobs, Hansjoerg Moest, Ulrich Omasits, Rebekah L. Gundry, Charles Yoon, Ralph Schiess, Alexander Schmidt, Paulina Mirkowska ...Show all 20 authors... , Anetta Svitorka Hartlova, Jennifer Eileen Van Eyk, Jean-Pierre Bourquin, Rudolf Aebersold, Kenneth R. Boheler, Peter W. Zandstra, Bernd Wollscheid; Show fewer authors
A mass spectrometric-derived cell surface protein atlas.
PLoS ONE 10:e0121314.1-e0121314.22(2015)

PubMed=26496030; DOI=10.18632/oncotarget.6171; PMCID=PMC4791243
Vikas Patil, Jagriti Pal, Kumaravel Somasundaram;
Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing.
Oncotarget 6:43452-43471(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer, Patricia Greninger, Ewald van Dyk ...Show all 39 authors... , Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27412690; DOI=10.1074/mcp.M116.060350; PMCID=PMC5013317
Bracha Shraibman, Dganit Melamed Kadosh, Eilon Barnea, Arie Admon;
Human leukocyte antigen (HLA) peptides derived from tumor antigens induced by inhibition of DNA methylation for development of drug-facilitated immunotherapy.
Mol. Cell. Proteomics 15:3058-3070(2016)

PubMed=27582061; DOI=10.1126/scitranslmed.aaf6853
Marie Allen, Mia Bjerke, Hanna Edlund, Sven Nelander, Bengt Westermark;
Origin of the U87MG glioma cell line: good news and bad news.
Sci. Transl. Med. 8:354re3.1-354re3.4(2016)

PubMed=27894925; DOI=10.1016/j.bbagen.2016.11.033
Mireia Casasampere, Yadira F. Ordonez, Josefina Casas, Gemma Fabrias;
Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms.
Biochim. Biophys. Acta 1861:264-275(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari, Sarah Harper, David Adam Jackson ...Show all 25 authors... , Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu, Alexander Y. Andreev-Drakhlin, Jaegil Kim ...Show all 68 authors... , Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji, Dale A. Porter, Tomas Rejtar ...Show all 20 authors... , Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=33385022; DOI=10.1016/j.dib.2020.106643; PMCID=PMC7772531
Juliana Ferreira de Sousa, Patrick da Silva, Rodolfo Bortolozo Serafim, Ricardo Perecin Nociti, Cristiano Gallina Moreira, Wilson Araujo Silva, Valeria Valente;
RNA sequencing data of different grade astrocytoma cell lines.
Data Brief 34:106643.1-106643.13(2021)

Cross-references
Cell line collections (Providers) Abcam; ab278079
AddexBio; C0005002/71
ATCC; HTB-14
BCRC; 60360
BCRJ; 0241
BEI_Resources; ARP-2188
CCTCC; GDC0157
CLS; 300367
ECACC; 89081402
IBRC; C10982
ICLC; HTL00013
IZSLER; BS TCL 189
KCB; KCB 2011101YJ
KCLB; 30014
NCBI_Iran; C531
RCB; RCB0419 - Discontinued
Ubigene; YC-C028
Cell line databases/resources CLO; CLO_0009463
CLO; CLO_0009464
MCCL; MCC:0000469
CLDB; cl4592
CLDB; cl4594
CLDB; cl4595
CLDB; cl7166
cancercelllines; CVCL_0022
CCRID; 1101HUM-PUMC000208
CCRID; 3101HUMTCHu138
Cell_Model_Passport; SIDM01189
CGH-DB; 157-1
Cosmic-CLP; 687590
DepMap; ACH-000075
LINCS_HMS; 50868
LINCS_LDP; LCL-1364
Lonza; 37
Lonza; 808
TOKU-E; 3381
Anatomy/cell type resources BTO; BTO_0002036
Biological sample resources BioSample; SAMN03472715
BioSample; SAMN03473126
BioSample; SAMN05292456
BioSample; SAMN07710026
BioSample; SAMN07710027
BioSample; SAMN07710028
BioSample; SAMN07710029
BioSample; SAMN07710030
BioSample; SAMN07710031
BioSample; SAMN07710032
BioSample; SAMN10988360
ENCODE; ENCBS424ENC
CRISP screens repositories BioGRID_ORCS_Cell_line; 348
Chemistry resources ChEMBL-Cells; CHEMBL3307575
ChEMBL-Cells; CHEMBL3989361
ChEMBL-Targets; CHEMBL614247
GDSC; 687590
PharmacoDB; U87MG_1623_2019
PubChem_Cell_line; CVCL_0022
Encyclopedic resources Wikidata; Q7863603
Experimental variables resources EFO; EFO_0005237
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM101676
GEO; GSM101686
GEO; GSM101687
GEO; GSM101688
GEO; GSM326243
GEO; GSM481417
GEO; GSM500897
GEO; GSM887723
GEO; GSM888817
GEO; GSM923437
GEO; GSM1374974
GEO; GSM1638668
GEO; GSM1670559
GEO; GSM2113436
GEO; GSM2113437
GEO; GSM2113438
GEO; GSM2113439
GEO; GSM7701418
GEO; GSM7701419
Metabolomic databases MetaboLights; MTBLS4708
MetaboLights; MTBLS6212
Polymorphism and mutation databases Cosmic; 687590
Cosmic; 849853
Cosmic; 850741
Cosmic; 850822
Cosmic; 920816
Cosmic; 1036336
Cosmic; 1064099
Cosmic; 1066234
Cosmic; 1171224
Cosmic; 1175825
Cosmic; 1198263
Cosmic; 1217671
Cosmic; 1219449
Cosmic; 1237542
Cosmic; 1294951
Cosmic; 1610737
Cosmic; 1746951
Cosmic; 1945859
Cosmic; 2302316
Cosmic; 2367555
Cosmic; 2491106
Cosmic; 2516044
Cosmic; 2550364
Cosmic; 2568870
Cosmic; 2580918
Cosmic; 2701083
IARC_TP53; 21096
LiGeA; CCLE_552
Progenetix; CVCL_0022
Proteomic databases PRIDE; PXD000589
PRIDE; PXD000661
PRIDE; PXD001565
PRIDE; PXD003790
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number49