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Cellosaurus U-87MG-parkin clone 7 (CVCL_C3IE)

[Text version]
Cell line name U-87MG-parkin clone 7
Synonyms U-87MG-PK7; U87-Parkin 7
Accession CVCL_C3IE
Resource Identification Initiative To cite this cell line use: U-87MG-parkin clone 7 (RRID:CVCL_C3IE)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Transfected with: HGNC; 8607; PRKN (with a N-terminal FLAG tag).
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Omics: Transcriptome analysis by microarray.
Sequence variations
  • Mutation; HGNC; 7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=22431710; DOI=10.1158/0008-5472.CAN-11-3060
Yeo C.W.-S., Ng F.S.L., Chai C., Tan J.M.-M., Koh G.R.-H., Chong Y.K., Koh L.W.-H., Foong C.S.F., Sandanaraj E., Holbrook J.D., Ang B.-T., Takahashi R., Tang C., Lim K.-L.
Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival.
Cancer Res. 72:2543-2553(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C3IE
Encyclopedic resources Wikidata; Q114313144
Gene expression databases GEO; GSM729739
GEO; GSM729742
GEO; GSM729745
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number4