ID   U-87MG-parkin clone 7
AC   CVCL_C3IE
SY   U-87MG-PK7; U87-Parkin 7
DR   cancercelllines; CVCL_C3IE
DR   GEO; GSM729739
DR   GEO; GSM729742
DR   GEO; GSM729745
DR   Wikidata; Q114313144
RX   PubMed=22431710;
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:8607; PRKN (Note=With a N-terminal FLAG tag).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Omics: Transcriptomics; Microarray.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 22-09-22; Last updated: 14-08-25; Version: 8
//
RX   PubMed=22431710; DOI=10.1158/0008-5472.CAN-11-3060;
RA   Yeo, Calvin W.-S.
RA   Ng, Felicia Soo Lee
RA   Chai, Chou
RA   Tan, Jeanne M.-M.
RA   Koh, Geraldene Rong-Hui
RA   Chong, Yuk Kien
RA   Koh, Lynnette Wei-Hsien
RA   Foong, Charlene S.F.
RA   Sandanaraj, Edwin
RA   Holbrook, Joanna Dawn
RA   Ang, Beng-Ti
RA   Takahashi, Ryosuke
RA   Tang, Carol
RA   Lim, Kah-Leong
RT   "Parkin pathway activation mitigates glioma cell proliferation and
RT   predicts patient survival.";
RL   Cancer Res. 72:2543-2553(2012).
//