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Cellosaurus U-87MG/DDP (CVCL_VL16)

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Cell line name U-87MG/DDP
Synonyms U87MG/DDP
Accession CVCL_VL16
Resource Identification Initiative To cite this cell line use: U-87MG/DDP (RRID:CVCL_VL16)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=24815474; DOI=10.7314/APJCP.2014.15.7.3219
Yu Zhu, Xing-Jun Liu, Ping Yang, Ming Zhao, Li-Xia Lv, Guo-Dong Zhang, Qin Wang, Ling Zhang;
Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines.
Asian Pac. J. Cancer Prev. 15:3219-3226(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_VL16
Anatomy/cell type resources BTO; BTO_0006083
Encyclopedic resources Wikidata; Q98133710
Entry history
Entry creation07-Sep-2018
Last entry update19-Dec-2024
Version number10