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Cellosaurus U-87MG EMC10 isoform HSS1 (CVCL_F1JR)

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Cell line name U-87MG EMC10 isoform HSS1
Synonyms U87 pcDNA3.1-hHSS1
Accession CVCL_F1JR
Resource Identification Initiative To cite this cell line use: U-87MG EMC10 isoform HSS1 (RRID:CVCL_F1JR)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Doubling time: 32.1 hours (PubMed=20680400).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:27609; EMC10 (Note=Isoform HSS1).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=20680400; DOI=10.1007/s11060-010-0314-6; PMCID=PMC3052511
Katiana S. Junes-Gill, Timothy K. Gallaher, Zoya Gluzman-Poltorak, Joseph D. Miller, Christopher J. Wheeler, Xue-Mo Fan, Lena A. Basile;
hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome 19q13.33.
J. Neurooncol. 102:197-211(2011)

Entry history
Entry creation27-Nov-2025
Last entry update27-Nov-2025
Version number1