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Cellosaurus U87MG-Venus-Akaluc (CVCL_E9YE)

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Cell line name U87MG-Venus-Akaluc
Accession CVCL_E9YE
Resource Identification Initiative To cite this cell line use: U87MG-Venus-Akaluc (RRID:CVCL_E9YE)
Comments Population: Caucasian.
Characteristics: Transduced with a hPGK-Venus-Akaluc-WPRE-mPGK-Neo construct (PubMed=33241215).
Genetic integration: Method=Transduction; Gene=FPbase; YUJWJ; Venus (Note=Bright yellow fluorescent protein derived from GFP).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transduction; Gene=Photinus pyralis Akaluciferase (Akaluc) (Note=A luciferase-derived fluorescent protein).
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=33241215; DOI=10.1093/noajnl/vdaa134; PMCID=PMC7680182
Dominique Bozec, Anirudh Sattiraju, Alexandros Bouras, Joe Gerald Jesu Raj, Daniel Rivera, Yong Huang, Chrystian Junqueira Alves, Rut Tejero, Nadejda M. Tsankova, Hong-Yan Zou, Constantinos Hadjipanayis, Roland Horst Friedel;
Akaluc bioluminescence offers superior sensitivity to track in vivo glioma expansion.
Neurooncol. Adv. 2:vdaa134.1-vdaa134.10(2020)

Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1