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Cellosaurus Abcam U-87MG STXBP1 KO (CVCL_E4AP)

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Cell line name Abcam U-87MG STXBP1 KO
Synonyms Human STXBP1 knockout U-87 MG
Accession CVCL_E4AP
Resource Identification Initiative To cite this cell line use: Abcam U-87MG STXBP1 KO (RRID:CVCL_E4AP)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Knockout cell: Method=CRISPR/Cas9; HGNC; HGNC:11444; STXBP1.
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

DOI=10.12688/f1000research.160174.1
Riham Ayoubi, Charles Alende, Maryam Fotouhi, Sara Gonzalez Bolivar, Carl Laflamme;
ABIF Consortium
NeuroSGC/YCharOS/EDDU Collaborative Group
A guide to selecting high-performing antibodies for STXBP1 (UniProt ID: P61764) for use in western blot, immunoprecipitation, and immunofluorescence.
F1000Research 13:1557.1-1557.12(2024)

Cross-references
Cell line collections (Providers) Abcam; ab322392
Entry history
Entry creation19-Dec-2024
Last entry update10-Apr-2025
Version number2