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Cellosaurus U87-MG/Pt (CVCL_4V16)

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Cell line name U87-MG/Pt
Accession CVCL_4V16
Resource Identification Initiative To cite this cell line use: U87-MG/Pt (RRID:CVCL_4V16)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

CLPUB00268
Tiziana Servidei, Daniela Meco, Roberta Morosetti, Anna Riccardi, Angela M. Di Francesco, Riccardo Riccardi, Carlo Dominici;
Cisplatin-resistant U87-MG/Pt glioblastoma cell line shows higher sensitivity to STI-571 compared to its parental cell line.
Proc. Am. Assoc. Cancer Res. 45:3876-3876(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4V16
Encyclopedic resources Wikidata; Q54973748
Polymorphism and mutation databases Cosmic; 1198264
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number12