ID   U87-MG/Pt
AC   CVCL_4V16
DR   cancercelllines; CVCL_4V16
DR   Cosmic; 1198264
DR   Wikidata; Q54973748
RX   CelloPub=CLPUB00268;
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Sequence variation: Mutation; HGNC; 7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 05-10-23; Version: 11
//
RX   CelloPub=CLPUB00268;
RA   Servidei T., Meco D., Morosetti R., Riccardi A., Di Francesco A.M.,
RA   Riccardi R., Dominici C.;
RT   "Cisplatin-resistant U87-MG/Pt glioblastoma cell line shows higher
RT   sensitivity to STI-571 compared to its parental cell line.";
RL   Proc. Am. Assoc. Cancer Res. 45:3876-3876(2004).
//