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Cellosaurus U87DND (CVCL_A5CL)

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Cell line name U87DND
Accession CVCL_A5CL
Resource Identification Initiative To cite this cell line use: U87DND (RRID:CVCL_A5CL)
Comments Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
Population: Caucasian.
Characteristics: Exhibits a remarkably low competence at producing ceramide de novo (PubMed=27894925).
Sequence variations
  • Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Glioblastoma (NCIt: C3058)
Glioblastoma (ORDO: Orphanet_360)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0022 (U-87MG ATCC)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=27894925; DOI=10.1016/j.bbagen.2016.11.033
Mireia Casasampere, Yadira F. Ordonez, Josefina Casas, Gemma Fabrias;
Dihydroceramide desaturase inhibitors induce autophagy via dihydroceramide-dependent and independent mechanisms.
Biochim. Biophys. Acta 1861:264-275(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5CL
Anatomy/cell type resources BTO; BTO_0006374
Encyclopedic resources Wikidata; Q107117181
Entry history
Entry creation20-May-2021
Last entry update19-Dec-2024
Version number5