ID   U87DND
AC   CVCL_A5CL
DR   BTO; BTO_0006374
DR   cancercelllines; CVCL_A5CL
DR   Wikidata; Q107117181
RX   PubMed=27894925;
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Characteristics: Exhibits a remarkably low competence at producing ceramide de novo (PubMed=27894925).
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 20-05-21; Last updated: 19-12-24; Version: 5
//
RX   PubMed=27894925; DOI=10.1016/j.bbagen.2016.11.033;
RA   Casasampere, Mireia
RA   Ordonez, Yadira F.
RA   Casas, Josefina
RA   Fabrias, Gemma
RT   "Dihydroceramide desaturase inhibitors induce autophagy via
RT   dihydroceramide-dependent and independent mechanisms.";
RL   Biochim. Biophys. Acta 1861:264-275(2017).
//