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Cellosaurus DT40 (CVCL_0249)

[Text version]

Cell line name DT40
Synonyms DT-40; DT 40; DT40B; LSCC-DT40
Accession CVCL_0249
Resource Identification Initiative To cite this cell line use: DT40 (RRID:CVCL_0249)
Comments Group: Bird cell line.
Doubling time: ~48 hours (DSMZ); ~1 day (lot 02272006) (JCRB).
Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
Omics: Deep proteome analysis.
Omics: Genome sequenced.
Derived from sampling site: Cell type=B-cell.
Disease Chicken bursal lymphoma (NCIt: C134556)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC.
Hierarchy Children:
CVCL_DD18 (D(Mh11)1 )CVCL_9084 (D33-3 )CVCL_9U92 (Delta-Rad51+hRad51-DT40 )
CVCL_9U93 (Delta-Rad54+hRad54-DT40 )CVCL_AS94 (Delta-Ubc9+cUbc9-DT40 )CVCL_J437 (DT40 CL18 )
CVCL_6D46 (DT40 Cre1 )CVCL_6D43 (DT40(v-myb)delta-pol-beta )CVCL_6D45 (DT40(v-myb)delta-pol-beta-delta-pol-lambda )
CVCL_6D44 (DT40(v-myb)delta-pol-lambda )CVCL_6D42 (DT40(v-myb)WT )CVCL_1T23 (DT40-ATM(-/-) )
CVCL_1T25 (DT40-BLM(-/-) )CVCL_2H96 (DT40-BLM(-/-)-WRN(-/-) )CVCL_1T38 (DT40-BLNK(-/-) )
CVCL_4E62 (DT40-BLNK(-/-)-GRB2(-/-) )CVCL_1T45 (DT40-BTK(-/-) )CVCL_1T40 (DT40-CARD11(-/-) )
CVCL_1T46 (DT40-CBL(-/-) )CVCL_1U33 (DT40-GRAP(-/-) )CVCL_1U32 (DT40-GRB2(-/-) )
CVCL_4E68 (DT40-GRB2(-/-)-GRAP(-/-) )CVCL_2G93 (DT40-INPP5D(-/-) )CVCL_8B31 (DT40-ITRP1(-/-)-ITPR2(-/-) )
CVCL_4634 (DT40-ITRP1(-/-)-ITPR2(-/-)-ITPR3(-/-) )CVCL_8B32 (DT40-ITRP1(-/-)-ITPR3(-/-) )CVCL_8B33 (DT40-ITRP2(-/-)-ITPR3(-/-) )
CVCL_1T44 (DT40-LIG4(-/-) )CVCL_1T41 (DT40-LYN(-/-) )CVCL_2H33 (DT40-LYN(-/-)-SYK(-/-) )
CVCL_1T50 (DT40-MAP3K7(-/-) )CVCL_JE98 (DT40-MRE11(-/-) clone #190 )CVCL_JE99 (DT40-MRE11(-/-) clone #194 )
CVCL_4Z66 (DT40-MRE11(-/-)-XRCC6(-/-) )CVCL_1T33 (DT40-NBN(-/-) )CVCL_1T26 (DT40-ORAI1(-/-) )
CVCL_1T27 (DT40-ORAI2(-/-) )CVCL_1T39 (DT40-PIK3AP1(-/-) )CVCL_4E64 (DT40-PIK3CA(-/-) )
CVCL_1T47 (DT40-PLCG2(-/-) )CVCL_1T32 (DT40-POLK(-/-) )CVCL_4E66 (DT40-POLK(-/-)-XPA(-/-) )
CVCL_1T42 (DT40-PRKCB(-/-) )CVCL_1Y06 (DT40-PRKDC(-/-) )CVCL_9Q56 (DT40-PRKDC(-/-)-XRCC6(-/-) )
CVCL_2G90 (DT40-PTPN11(-/-) )CVCL_2G91 (DT40-PTPN6(-/-) )CVCL_1U31 (DT40-RAD18(-/-) )
CVCL_4E67 (DT40-RAD18(-/-)-POLK(-/-) )CVCL_4E65 (DT40-RAD18(-/-)-XPA(-/-) )CVCL_X637 (DT40-RAD51B(-/-) )
CVCL_X638 (DT40-RAD51C(-/-) )CVCL_X639 (DT40-RAD51D(-/-) )CVCL_X640 (DT40-RAD52(-/-) )
CVCL_2H95 (DT40-RAD52(-/-)-XRCC3(-/-) )CVCL_6D41 (DT40-RAD54B(-/-)-XRCC6(-/-) )CVCL_1Y07 (DT40-RAD54L(-/-)-RAD54B(-/-) )
CVCL_4W13 (DT40-RAD54L(-/-)-XRCC6(-/-) )CVCL_1U38 (DT40-RASGRP1(-/-) )CVCL_1U39 (DT40-RASGRP1(-/-)-RASGRP3(-/-) )
CVCL_1U40 (DT40-RASGRP3(-/-) )CVCL_1U34 (DT40-SHC1(-/-) )CVCL_1U35 (DT40-SOS1(-/-) )
CVCL_1U37 (DT40-SOS1(-/-)-SOS2(-/-) )CVCL_1U36 (DT40-SOS2(-/-) )CVCL_1T28 (DT40-STIM1(-/-) )
CVCL_1T29 (DT40-STIM1(-/-)-STIM2(-/-) )CVCL_1T30 (DT40-STIM2(-/-) )CVCL_1T43 (DT40-SYK(-/-) )
CVCL_2I01 (DT40-TRPC1(-/-) )CVCL_1T49 (DT40-VAV3(-/-) )CVCL_1T35 (DT40-WRN(-/-) )
CVCL_1T36 (DT40-XRCC2(-/-) )CVCL_2G89 (DT40-XRCC3(+/-) )CVCL_1T37 (DT40-XRCC3(-/-) )
CVCL_1T31 (DT40-XRCC6(-/-) )CVCL_WK49 (iLite IL-2 Assay Ready Cells )CVCL_C0TX (JPR3 )
CVCL_1R68 (MSH6-1-[ClX3.16]DT40 )
Sex of cell Female
Age at sampling 1D
Category Cancer cell line
Web pages https://web.archive.org/web/20151216020045/http://www2.mrc-lmb.cam.ac.uk/groups/jes/pages/dt40.html

PubMed=2998040; DOI=10.1016/0042-6822(85)90312-5
Baba T.W., Giroir B.P., Humphries E.H.
Cell lines derived from avian lymphomas exhibit two distinct phenotypes.
Virology 144:139-151(1985)

PubMed=18766641; DOI=10.1080/03079458708436402
Nazerian K.
An updated list of avian cell lines and transplantable tumours.
Avian Pathol. 16:527-544(1987)

PubMed=11226459; DOI=10.1016/S0022-1759(00)00333-1
Winding P., Berchtold M.W.
The chicken B cell line DT40: a novel tool for gene disruption experiments.
J. Immunol. Methods 249:1-16(2001)

PubMed=17675859; DOI=10.1159/000103179
Bachl J., Caldwell R.B., Buerstedde J.-M.
Biotechnology and the chicken B cell line DT40.
Cytogenet. Genome Res. 117:189-194(2007)

PubMed=19181659; DOI=10.1074/mcp.M800394-MCP200
Hall S.L., Hester S., Griffin J.L., Lilley K.S., Jackson A.P.
The organelle proteome of the DT40 lymphocyte cell line.
Mol. Cell. Proteomics 8:1295-1305(2009)

PubMed=25227228; DOI=10.1534/g3.114.013482
Molnar J., Poti A., Pipek O., Krzystanek M., Kanu N., Swanton C., Tusnady G.E., Szallasi Z., Csabai I., Szuts D.
The genome of the chicken DT40 bursal lymphoma cell line.
G3 (Bethesda) 4:2231-2240(2014)

PubMed=26217713; DOI=10.1016/j.dib.2014.12.006
Rees J.S., Lilley K.S., Jackson A.P.
The chicken B-cell line DT40 proteome, beadome and interactomes.
Data Brief 3:29-33(2015)

Cell line collections ATCC; CRL-2111
NCBI_Iran; C618
RCB; RCB1464
Cell line databases/resources CLO; CLO_0002837
CLO; CLO_0051524
MCCL; MCC:0000139
DSMZCellDive; ACC-636
Lonza; 267
TOKU-E; 1101
Anatomy/cell type resources BTO; BTO:0004814
Encyclopedic resources Wikidata; Q54831466
Experimental variables resources EFO; EFO_0006274
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number25