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Cellosaurus DT40-PLCG2(-/-) (CVCL_1T47)

[Text version]

Cell line name DT40-PLCG2(-/-)
Synonyms PLC-gamma2^(-) DT40
Accession CVCL_1T47
Resource Identification Initiative To cite this cell line use: DT40-PLCG2(-/-) (RRID:CVCL_1T47)
Comments Group: Bird cell line.
Knockout cell: Method=Targeted integration; PLCG2.
Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
Derived from sampling site: Cell type=B-cell.
Disease Chicken bursal lymphoma (NCIt: C134556)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC.
Hierarchy Parent: CVCL_0249 (DT40)
Sex of cell Female
Age at sampling 1D
Category Cancer cell line
Publications

PubMed=9763608; DOI=10.1084/jem.188.7.1287
Hashimoto A., Okada H., Jiang A., Kurosaki M., Greenberg S., Clark E.A., Kurosaki T.
Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor.
J. Exp. Med. 188:1287-1295(1998)

PubMed=14676298; DOI=10.1084/jem.20031547
Oh-hora M., Johmura S., Hashimoto A., Hikida M., Kurosaki T.
Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling.
J. Exp. Med. 198:1841-1851(2003)

Cross-references
Cell line collections RCB; RCB1469
Cell line databases/resources CLO; CLO_0051477
Encyclopedic resources Wikidata; Q54831503
Entry history
Entry creation08-Jul-2015
Last entry update17-Mar-2022
Version number7