Cellosaurus cell line DT40-PLCG2(-/-) (CVCL

Cellosaurus DT40-PLCG2(-/-) (CVCL_1T47)

Cross-references
Cell line name	DT40-PLCG2(-/-)
Synonyms	PLC-gamma2^(-) DT40
Accession	CVCL_1T47
Resource Identification Initiative	To cite this cell line use: DT40-PLCG2(-/-) (RRID:CVCL_1T47)
Comments	Group: Bird cell line. Knockout cell: Method=Targeted integration; CGNC; 4062; PLCG2. Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV). Cell type: B-cell; CL=CL_0000236.
Disease	Chicken bursal lymphoma (NCIt: C134556)
Species of origin	Gallus gallus (Chicken) (NCBI Taxonomy: 9031) Breed/subspecies: Hy-Line SC.
Hierarchy	Parent: CVCL_0249 (DT40)
Sex of cell	Female
Age at sampling	1D
Category	Cancer cell line
Publications	PubMed=9763608; DOI=10.1084/jem.188.7.1287; PMCID=PMC2212492 Hashimoto A., Okada H., Jiang A.-M., Kurosaki M., Greenberg S., Clark E.A., Kurosaki T. Involvement of guanosine triphosphatases and phospholipase C-gamma2 in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase activation by the B cell antigen receptor. J. Exp. Med. 188:1287-1295(1998) PubMed=14676298; DOI=10.1084/jem.20031547; PMCID=PMC2194160 Oh-hora M., Johmura S., Hashimoto A., Hikida M., Kurosaki T. Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J. Exp. Med. 198:1841-1851(2003)
Cell line collections (Providers)	RCB; RCB1469
Cell line databases/resources	CLO; CLO_0051477
Encyclopedic resources	Wikidata; Q54831503
Entry history
Entry creation	08-Jul-2015
Last entry update	10-Sep-2024
Version number	11