ID   DT40-PLCG2(-/-)
AC   CVCL_1T47
SY   PLC-gamma2^(-) DT40
DR   CLO; CLO_0051477
DR   RCB; RCB1469
DR   Wikidata; Q54831503
RX   PubMed=9763608;
RX   PubMed=14676298;
CC   Group: Bird cell line.
CC   Knockout cell: Method=Targeted integration; UniProtKB; A0A8V0XUR6; PLCG2.
CC   Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
CC   Cell type: B-cell; CL=CL_0000236.
CC   Breed/subspecies: Hy-Line SC.
DI   NCIt; C134556; Chicken bursal lymphoma
OX   NCBI_TaxID=9031; ! Gallus gallus (Chicken)
HI   CVCL_0249 ! DT40
SX   Female
AG   1D
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 30-01-24; Version: 10
//
RX   PubMed=9763608; DOI=10.1084/jem.188.7.1287;
RA   Hashimoto A., Okada H., Jiang A.-M., Kurosaki M., Greenberg S.,
RA   Clark E.A., Kurosaki T.;
RT   "Involvement of guanosine triphosphatases and phospholipase C-gamma2
RT   in extracellular signal-regulated kinase, c-Jun NH2-terminal kinase,
RT   and p38 mitogen-activated protein kinase activation by the B cell
RT   antigen receptor.";
RL   J. Exp. Med. 188:1287-1295(1998).
//
RX   PubMed=14676298; DOI=10.1084/jem.20031547;
RA   Oh-hora M., Johmura S., Hashimoto A., Hikida M., Kurosaki T.;
RT   "Requirement for Ras guanine nucleotide releasing protein 3 in
RT   coupling phospholipase C-gamma2 to Ras in B cell receptor signaling.";
RL   J. Exp. Med. 198:1841-1851(2003).
//