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Cellosaurus DT40-MRE11(-/-)-XRCC6(-/-) (CVCL_4Z66)

[Text version]
Cell line name DT40-MRE11(-/-)-XRCC6(-/-)
Synonyms Delta-Mre11-delta-Ku70-DT40; DT40 MRE11-/-/KU70-/-
Accession CVCL_4Z66
Resource Identification Initiative To cite this cell line use: DT40-MRE11(-/-)-XRCC6(-/-) (RRID:CVCL_4Z66)
Comments Group: Bird cell line.
Knockout cell: Method=Targeted integration; CGNC; 12932; MRE11.
Knockout cell: Method=Targeted integration; CGNC; 9044; XRCC6.
Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
Cell type: B-cell; CL=CL_0000236.
Disease Chicken bursal lymphoma (NCIt: C134556)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC.
Hierarchy Parent: CVCL_0249 (DT40)
Sex of cell Female
Age at sampling 1D
Category Cancer cell line
Publications

PubMed=10581236; DOI=10.1093/emboj/18.23.6619; PMCID=PMC1171725
Yuko Yamaguchi-Iwai, Eiichiro Sonoda, Masao S. Sasaki, Ciaran Morrison, Tokuko Haraguchi, Yasushi Hiraoka, Yukiko M. Yamashita, Takashi Yagi, Minoru Takata, Carolyn Price, Naoki Kakazu, Shunichi Takeda;
Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells.
EMBO J. 18:6619-6629(1999)

Cross-references
Cell line collections (Providers) RCB; RCB1633
Cell line databases/resources CLO; CLO_0051530
Encyclopedic resources Wikidata; Q54831497
Entry history
Entry creation14-Dec-2015
Last entry update10-Sep-2024
Version number12