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Cellosaurus DT40-MRE11(-/-)-XRCC6(-/-) (CVCL_4Z66)

[Text version]
Cell line name DT40-MRE11(-/-)-XRCC6(-/-)
Synonyms Delta-Mre11-delta-Ku70-DT40; DT40 MRE11-/-/KU70-/-
Accession CVCL_4Z66
Resource Identification Initiative To cite this cell line use: DT40-MRE11(-/-)-XRCC6(-/-) (RRID:CVCL_4Z66)
Comments Group: Bird cell line.
Knockout cell: Method=Targeted integration; UniProtKB; Q9IAM7; MRE11.
Knockout cell: Method=Targeted integration; UniProtKB; O93257; XRCC6.
Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
Cell type: B-cell; CL=CL_0000236.
Disease Chicken bursal lymphoma (NCIt: C134556)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC.
Hierarchy Parent: CVCL_0249 (DT40)
Sex of cell Female
Age at sampling 1D
Category Cancer cell line
Publications

PubMed=10581236; DOI=10.1093/emboj/18.23.6619
Yamaguchi-Iwai Y., Sonoda E., Sasaki M.S., Morrison C., Haraguchi T., Hiraoka Y., Yamashita Y.M., Yagi T., Takata M., Price C., Kakazu N., Takeda S.
Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells.
EMBO J. 18:6619-6629(1999)

Cross-references
Cell line collections (Providers) RCB; RCB1633
Cell line databases/resources CLO; CLO_0051530
Encyclopedic resources Wikidata; Q54831497
Entry history
Entry creation14-Dec-2015
Last entry update30-Jan-2024
Version number11