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Cellosaurus DT40-ITRP1(-/-)-ITPR2(-/-)-ITPR3(-/-) (CVCL_4634)

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Cell line name DT40-ITRP1(-/-)-ITPR2(-/-)-ITPR3(-/-)
Synonyms IP3R^(-) DT40; DT40-3KO; DT40 3KO; DT-40 3KO; Dt-40 3ko
Accession CVCL_4634
Secondary accession CVCL_8B34
Resource Identification Initiative To cite this cell line use: DT40-ITRP1(-/-)-ITPR2(-/-)-ITPR3(-/-) (RRID:CVCL_4634)
Comments Group: Bird cell line.
Knockout cell: Method=Targeted integration; CGNC; 49305; ITPR1.
Knockout cell: Method=Targeted integration; CGNC; 10502; ITPR2.
Knockout cell: Method=Targeted integration; CGNC; 2283; ITPR3.
Transformant: NCBI_TaxID; 11864; Avian leukosis virus (ALV).
Cell type: B-cell; CL=CL_0000236.
Disease Chicken bursal lymphoma (NCIt: C134556)
Species of origin Gallus gallus (Chicken) (NCBI Taxonomy: 9031)
Breed/subspecies: Hy-Line SC.
Hierarchy Parent: CVCL_0249 (DT40)
Sex of cell Female
Age at sampling 1D
Category Cancer cell line
Publications

PubMed=9214625; DOI=10.1093/emboj/16.11.3078; PMCID=PMC1169926
Hitoshi Sugawara, Mari Kurosaki, Minoru Takata, Tomohiro Kurosaki;
Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor.
EMBO J. 16:3078-3088(1997)

PubMed=27048566; DOI=10.1126/scisignal.aad6281; PMCID=PMC4850551
Kamil J. Alzayady, Li-Wei Wang, Rahul Chandrasekhar, Larry E. Wagner 2nd, Filip Van Petegem, David I. Yule;
Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.
Sci. Signal. 9:Ra35.1-Ra35.13(2016)

Cross-references
Cell line collections (Providers) RCB; RCB1467
Cell line databases/resources CLO; CLO_0051504
Anatomy/cell type resources BTO; BTO_0005034
Encyclopedic resources Wikidata; Q54831488
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number17