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Cellosaurus PC-9 (CVCL_B260)

[Text version]
Cell line name PC-9
Synonyms PC9; PC-9/S1; PC-9S1
Accession CVCL_B260
Resource Identification Initiative To cite this cell line use: PC-9 (RRID:CVCL_B260)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
From: Immuno-Biological Laboratories (IBL); Tokyo; Japan.
Population: Chinese; Han and Japanese.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Phosphorylation.
Omics: Proteomics; Subcellular; Membrane.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
HLA typing Source: PubMed=9178645
Class I
HLA-AA*02:06,24:02
HLA-BB*07:02,55:02
HLA-CC*03:03,07:02
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E3IE (HyCyte PC-9-Luc)CVCL_E3IF (HyCyte PC-9-Luc-GFP)CVCL_1640 (PC-14)
CVCL_S706 (PC-9-GR-high)CVCL_S707 (PC-9-GR-step)CVCL_T015 (PC-9/BR)
CVCL_ZZ72 (PC-9/CDDP)CVCL_DG28 (PC-9/ER/WR)CVCL_D778 (PC-9/ER1)
CVCL_D726 (PC-9/ER3)CVCL_U150 (PC-9/f9)CVCL_E7RA (PC-9/GR)
CVCL_DG27 (PC-9/GR/WR)CVCL_DI28 (PC-9/GR1)CVCL_DI29 (PC-9/GR2)
CVCL_DI30 (PC-9/GR3)CVCL_DH34 (PC-9/GR4)CVCL_DI31 (PC-9/GR5)
CVCL_DI32 (PC-9/GR6)CVCL_DP47 (PC-9/IR)CVCL_S750 (PC-9/R)
CVCL_T016 (PC-9/S2)CVCL_DG29 (PC-9/WR)CVCL_V337 (PC-9/ZD)
CVCL_E8FK (PC-9(gFGFR1))CVCL_E4DL (PC9 BIR)CVCL_E6ZD (PC9 fat-1)
CVCL_S977 (PC9-DPE2)CVCL_D7FL (PC9-OR#1)CVCL_D7FM (PC9-OR#2)
CVCL_D7FN (PC9-OR#3)CVCL_D7FG (PC9-OR1)CVCL_D7FH (PC9-OR2)
CVCL_D7FI (PC9-OR3)CVCL_D7FJ (PC9-OR4)CVCL_D7FK (PC9-OR5)
CVCL_XA18 (PC9-TGL)CVCL_E4DE (PC9/3-14)CVCL_E4DF (PC9/3-2)
CVCL_B7N9 (PC9/TS1)CVCL_B7NA (PC9/TS2)CVCL_B263 (RPC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
STR profile Source(s): PubMed=25877200; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO11
D1S165615
D2S44111
D2S133819,20
D3S135816
D5S81811
D7S82010,11
D8S117911,15
D10S124813
D12S39118
D13S3178
D16S5399
D18S5115
D19S43313,15.2
D21S1130
D22S104516,17
FGA23
Penta D13
Penta E11
TH017
TPOX11
vWA17

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=758928; DOI=10.1038/bjc.1979.3; PMCID=PMC2009802
Mitsuru Kinjo, Kazunari Oka, S. Naito, Shin Kohga, Kenzo Tanaka, Shoichi Oboshi, Yoshihiro Hayata, Kosei Yasumoto;
Thromboplastic and fibrinolytic activities of cultured human cancer cell lines.
Br. J. Cancer 39:15-23(1979)

DOI=10.5795/jjscc.24.451
Masaru Tsumuraya, Takashi Nakajima, Takeo Terasaki, Tetsuro Kodama, Yukio Shimosato, Hisaaki Higuchi, Yoshio Uei;
Analysis of LDH isoenzyme patterns in cell lines of the small cell carcinoma (lung) and retinoblastoma.
Nihon Rinsho Saibo Gakkai Zasshi 24:451-456(1985)

PubMed=4094096; DOI=10.1093/oxfordjournals.jjco.a039097
Yung-Chie Lee, Nagahiro Saijo, Yasutsuna Sasaki, Hidenobu Takahashi, Masanori Sakurai, Junichi Ishihara, Akio Hoshi, Kai-Mo Chen, Anne W. Hamburger;
Clonogenic patterns of human pulmonary adenocarcinoma cell lines (PC-9, PC-13 and PC-14) and how they influence the results of test for chemosensitivity to cisplatin in the human tumor clonogenic assay.
Jpn. J. Clin. Oncol. 15:637-644(1985)

PubMed=1847845; DOI=10.1007/BF00685110
Yasutsuna Sasaki, Tetsu Shinkai, Kenji Eguchi, Tomohide Tamura, Yuichiro Ohe, Tohru Ohmori, Nagahiro Saijo;
Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay.
Cancer Chemother. Pharmacol. 27:263-270(1991)

PubMed=1737336
Ichiro Yoshino, Tokujiro Yano, Mitsuhiro Murata, Teruyoshi Ishida, Keizo Sugimachi, Genki Kimura, Kikuo Nomoto;
Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor.
Cancer Res. 52:775-781(1992)

PubMed=8263009; DOI=10.1007/BF01202192
Tatsuhiko Kashii, Yutaka Mizushima, Satoshi Monno, K. Nakagawa, M. Kobayashi;
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
J. Cancer Res. Clin. Oncol. 120:143-148(1994)

PubMed=9023415; DOI=10.1006/cimm.1996.1062
Naoko Seki, Tomoaki Hoshino, Megumi Kikuchi, Akihiro Hayashi, Kyogo Itoh;
HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating lymphocytes of patients with non-small cell lung cancer.
Cell. Immunol. 175:101-110(1997)

PubMed=9178645; DOI=10.1006/cimm.1997.1108
Masanobu Nakao, Michio Sata, Hideki Saitsu, Shigeru Yutani, Mayumi Kawamoto, Masamichi Kojiro, Kyogo Itoh;
CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma.
Cell. Immunol. 177:176-181(1997)

PubMed=9538136; DOI=10.3892/ijo.12.5.1103
Toshiyuki Takaki, Akio Hiraki, Akiko Uenaka, Shinya Gomi, Kyogo Itoh, Heiichiro Udono, Akira Shibuya, Takao Tsuji, Sadayoshi Sekiguchi, Eiichi Nakayama;
Variable expression on lung cancer cell lines of HLA-A2-binding MAGE-3 peptide recognized by cytotoxic T lymphocytes.
Int. J. Oncol. 12:1103-1109(1998)

PubMed=10536175; DOI=10.3892/ijo.15.5.927
Takeshi Fujita, Masaharu Kiyama, Yoshio Tomizawa, Takashi Kohno, Jun Yokota;
Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.
Int. J. Oncol. 15:927-934(1999)

PubMed=11005564; DOI=10.1038/sj.neo.7900094; PMCID=PMC1550293
Takashi Kohno, Takako Sato, Satoshi Takakura, Kimiko Takei, Kaoru Inoue, Michiho Nishioka, Jun Yokota;
Mutation and expression of the DCC gene in human lung cancer.
Neoplasia 2:300-305(2000)

PubMed=11078804; DOI=10.3892/ijo.17.6.1187
Kiyoshi Takenaka, Masahiko Shibuya, Yuichiro Takeda, Suguru Hibino, Akihiko Gemma, Yasushi Ono, Shoji Kudoh;
Altered expression and function of beta1 integrins in a highly metastatic human lung adenocarcinoma cell line.
Int. J. Oncol. 17:1187-1194(2000)

PubMed=16105816; DOI=10.1158/0008-5472.CAN-05-0331
Yoshiaki Nagai, Hitoshi Miyazawa, Huqun No_last_name, Tomoaki Tanaka, Kiyoshi Udagawa, Motoyasu Kato, Shunichiro Fukuyama, Akemi Yokote, Kunihiko Kobayashi, Minoru Kanazawa, Koichi Hagiwara;
Genetic heterogeneity of the epidermal growth factor receptor in non-small cell lung cancer cell lines revealed by a rapid and sensitive detection system, the peptide nucleic acid-locked nucleic acid PCR clamp.
Cancer Res. 65:7276-7282(2005)

PubMed=17332333; DOI=10.1158/0008-5472.CAN-06-3339
Takafumi Okabe, Isamu Okamoto, Kenji Tamura, Masaaki Terashima, Takeshi Yoshida, Taroh Satoh, Minoru Takada, Masahiro Fukuoka, Kazuhiko Nakagawa;
Differential constitutive activation of the epidermal growth factor receptor in non-small cell lung cancer cells bearing EGFR gene mutation and amplification.
Cancer Res. 67:2046-2053(2007)

PubMed=17511773; DOI=10.1111/j.1349-7006.2007.00507.x; PMCID=PMC11159702
Takashi Fukuyama, Yoshinobu Ichiki, Sousuke Yamada, Yoshiki Shigematsu, Tetsuro Baba, Yoshika Nagata, Makiko Mizukami, Masakazu Sugaya, Mitsuhiro Takenoyama, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto;
Cytokine production of lung cancer cell lines: correlation between their production and the inflammatory/immunological responses both in vivo and in vitro.
Cancer Sci. 98:1048-1054(2007)

PubMed=19472407; DOI=10.1002/humu.21028; PMCID=PMC2900846
Raquel Blanco, Reika Iwakawa, Mo-Ying Tang, Takashi Kohno, Barbara Angulo, Ruben Pio, Luis M. Montuenga, John D. Minna, Jun Yokota, Montse Sanchez-Cespedes;
A gene-alteration profile of human lung cancer cell lines.
Hum. Mutat. 30:1199-1206(2009)

PubMed=19799608; DOI=10.1111/j.1349-7006.2009.01351.x; PMCID=PMC11159900
Koji Kuroda, Mitsuhiro Takenoyama, Tetsuro Baba, Yoshiki Shigematsu, Hironobu Shiota, Yoshinobu Ichiki, Manabu Yasuda, Hidetaka Uramoto, Takeshi Hanagiri, Kosei Yasumoto;
Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma.
Cancer Sci. 101:46-53(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20557307; DOI=10.1111/j.1349-7006.2010.01622.x; PMCID=PMC11158680
Reika Iwakawa, Takashi Kohno, Masatoshi Enari, Tohru Kiyono, Jun Yokota;
Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma.
Cancer Sci. 101:1891-1896(2010)

PubMed=22313637; DOI=10.4161/cbt.19238
Miyako Takata, Hiroki Chikumi, Naomi Miyake, Kaori Adachi, Yasunobu Kanamori, Akira Yamasaki, Tadashi Igishi, Naoto Burioka, Eiji Nanba, Eiji Shimizu;
Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity.
Cancer Biol. Ther. 13:369-378(2012)

PubMed=23733853; DOI=10.1101/gr.152322.112; PMCID=PMC3759720
Pei-Lin Jia, Hai-Ling Jin, Catherine Belle Meador, Jun-Feng Xia, Kadoaki Ohashi, Lin Liu, Valentina Pirazzoli, Kimberly Brown Dahlman, Katerina Politi, Franziska Michor, Zhong-Ming Zhao, William Pao;
Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.
Genome Res. 23:1434-1445(2013)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26202522; DOI=10.1021/acs.jproteome.5b00477; PMCID=PMC4761227
Reta Birhanu Kitata, Baby Rorielyn T. Dimayacyac-Esleta, Wai-Kok Choong, Chia-Feng Tsai, Tai-Du Lin, Chih-Chiang Tsou, Shao-Hsing Weng, Yi-Ju Chen, Pan-Chyr Yang, Susan D. Arco, Alexey I. Nesvizhskii ...Show all 13 authors... , Ting-Yi Sung, Yu-Ju Chen; Show fewer authors
Mining missing membrane proteins by high-pH reverse-phase stagetip fractionation and multiple reaction monitoring mass spectrometry.
J. Proteome Res. 14:3658-3669(2015)

PubMed=26554430; DOI=10.1021/acs.analchem.5b03639
Baby Rorielyn T. Dimayacyac-Esleta, Chia-Feng Tsai, Reta Birhanu Kitata, Pei-Yi Lin, Wai-Kok Choong, Tai-Du Lin, Yi-Ting Wang, Shao-Hsing Weng, Pan-Chyr Yang, Susan D. Arco, Ting-Yi Sung, Yu-Ju Chen;
Rapid high-pH reverse phase stagetip for sensitive small-scale membrane proteomic profiling.
Anal. Chem. 87:12016-12023(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28290473; DOI=10.1038/srep44021; PMCID=PMC5349541
Yi-Ting Wang, Szu-Hua Pan, Chia-Feng Tsai, Ting-Chun Kuo, Yuan-Ling Hsu, Hsin-Yung Yen, Wai-Kok Choong, Hsin-Yi Wu, Yen-Chen Liao, Tse-Ming Hong, Ting-Yi Sung ...Show all 13 authors... , Pan-Chyr Yang, Yu-Ju Chen; Show fewer authors
Phosphoproteomics reveals HMGA1, a CK2 substrate, as a drug-resistant target in non-small cell lung cancer.
Sci. Rep. 7:44021-44021(2017)

PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540
Elizabeth A. McMillan, Myung-Jeom Ryu, Caroline H. Diep, Saurabh Mendiratta, Jean Rene Clemenceau, Rachel M. Vaden, Ju-Hwa Kim, Takashi Motoyaji, Kyle R. Covington, Michael Peyton, Kenneth Huffman ...Show all 40 authors... , Xiao-Feng Wu, Luc Girard, Yeojin Sung, Pei-Hsaun Chen, Prema Latha Mallipeddi, Joo Young Lee, Jordan Hanson, Sukesh Voruganti, Yunku Yu, Sunho Park, Jessica Sudderth, Christopher DeSevo, Donna M. Muzny, HarshaVardhan Doddapaneni, Adi F. Gazdar, Richard Alexander Gibbs, Tae Hyun Hwang, John Victor Heymach, Ignacio Ivan Wistuba, Kevin Robert Coombes, Noelle S. Williams, David A. Wheeler, John B. MacMillan, Ralph J. DeBerardinis, Michael G. Roth, Bruce Arthur Posner, John D. Minna, Hyun Seok Kim, Michael A. White; Show fewer authors
Chemistry-first approach for nomination of personalized treatment in lung cancer.
Cell 173:864-878.e29(2018)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=34320349; DOI=10.1016/j.celrep.2021.109441; PMCID=PMC8333195
Fleur Jochems, Bram Thijssen, Giulia De Conti, Robin Jansen, Ziva Pogacar, Kelvin Groot, Li-Qin Wang, Arnout Schepers, Cun Wang, Hao-Jie Jin, Roderick L. Beijersbergen ...Show all 14 authors... , Rodrigo Leite de Oliveira, Lodewyk F.A. Wessels, Rene Bernards; Show fewer authors
The cancer SENESCopedia: a delineation of cancer cell senescence.
Cell Rep. 36:109441.1-109441.22(2021)

PubMed=38639832; DOI=10.1007/s13577-024-01055-0; PMCID=PMC11194210
Fumio Kasai, Makoto Fukushima, Yohei Miyagi, Yukio Nakamura;
Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan.
Hum. Cell 37:944-950(2024)

PubMed=39061985; DOI=10.3390/biomedicines12071412; PMCID=PMC11273927
Shota Fukuda, Kenichi Suda, Akira Hamada, Hana Oiki, Shuta Ohara, Masaoki Ito, Junichi Soh, Tetsuya Mitsudomi, Yasuhiro Tsutani;
Potential utility of a 4th-generation EGFR-TKI and exploration of resistance mechanisms -- an in vitro study.
Biomedicines 12:1412.1-1412.13(2024)

Cross-references
Cell line collections (Providers) BCRJ; 0331
CLS; 305045
RCB; RCB4455
Ubigene; YC-C114
Cell line databases/resources CLO; CLO_0050067
cancercelllines; CVCL_B260
Cell_Model_Passport; SIDM00236
DepMap; ACH-000779
IGRhCellID; PC9GEO
LINCS_HMS; 50038
LINCS_LDP; LCL-1630
Anatomy/cell type resources BTO; BTO_0005518
Biological sample resources BioSample; SAMN03470946
BioSample; SAMN10989619
ENCODE; ENCBS177ANS
ENCODE; ENCBS480XRH
ENCODE; ENCBS761VSF
ENCODE; ENCBS987JQH
CRISP screens repositories BioGRID_ORCS_Cell_line; 1203
Chemistry resources ChEMBL-Cells; CHEMBL3307867
ChEMBL-Targets; CHEMBL614102
PubChem_Cell_line; CVCL_B260
Encyclopedic resources Wikidata; Q54938469
Experimental variables resources EFO; EFO_0002847
Gene expression databases GEO; GSM434290
GEO; GSM481160
GEO; GSM784274
GEO; GSM794406
GEO; GSM827407
GEO; GSM1374821
GEO; GSM5599283
Polymorphism and mutation databases Cosmic; 713867
Cosmic; 801574
Cosmic; 876137
Cosmic; 897746
Cosmic; 911753
Cosmic; 915329
Cosmic; 917985
Cosmic; 929156
Cosmic; 946058
Cosmic; 1001658
Cosmic; 1002731
Cosmic; 1047092
Cosmic; 1128254
Cosmic; 1146943
Cosmic; 1239896
Cosmic; 1336875
Cosmic; 1571735
Cosmic; 1656893
Cosmic; 1731370
Cosmic; 1745414
Cosmic; 2015224
Cosmic; 2125285
Cosmic; 2668307
IARC_TP53; 2385
Progenetix; CVCL_B260
Proteomic databases PRIDE; PXD001548
PRIDE; PXD002224
Entry history
Entry creation06-Jun-2012
Last entry update10-Apr-2025
Version number42