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Cellosaurus PC-9/R (CVCL_S750)

[Text version]
Cell line name PC-9/R
Synonyms PC-9R; PC-9/ER; PC-9ER
Accession CVCL_S750
Resource Identification Initiative To cite this cell line use: PC-9/R (RRID:CVCL_S750)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=22773810).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=21734175; DOI=10.1126/scitranslmed.3002356; PMCID=PMC3500629
Juliann Chmielecki, Jasmine Foo, Geoffrey Raymond Oxnard, Katherine Hutchinson, Kadoaki Ohashi, Romel Somwar, Lu Wang, Katherine R. Amato, Maria E. Arcila, Martin L. Sos, Nicholas Donald Socci ...Show all 21 authors... , Agnes J. Viale, Elisa de Stanchina, Michelle S. Ginsberg, Roman Kurt Thomas, Mark G. Kris, Akira Inoue, Marc Ladanyi, Vincent A. Miller, Franziska Michor, William Pao; Show fewer authors
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.
Sci. Transl. Med. 3:90ra59.1-90ra59.10(2011)

PubMed=22773810; DOI=10.1073/pnas.1203530109; PMCID=PMC3411967
Kadoaki Ohashi, Lecia VanDam Sequist, Maria E. Arcila, Teresa Moran, Juliann Chmielecki, Ya-Lun Lin, Yu-Mei Pan, Lu Wang, Elisa de Stanchina, Kazuhiko Shien, Keisuke Aoe ...Show all 24 authors... , Shinichi Toyooka, Katsuyuki Kiura, Lynnette Fernandez-Cuesta, Panos Fidias, James Chih-Hsin Yang, Vincent A. Miller, Gregory J. Riely, Mark G. Kris, Jeffrey Adam Engelman, Cindy L. Vnencak-Jones, Dora Dias-Santagata, Marc Ladanyi, William Pao; Show fewer authors
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012)

PubMed=23733853; DOI=10.1101/gr.152322.112; PMCID=PMC3759720
Pei-Lin Jia, Hai-Ling Jin, Catherine Belle Meador, Jun-Feng Xia, Kadoaki Ohashi, Lin Liu, Valentina Pirazzoli, Kimberly Brown Dahlman, Katerina Politi, Franziska Michor, Zhong-Ming Zhao, William Pao;
Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.
Genome Res. 23:1434-1445(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S750
Encyclopedic resources Wikidata; Q54938502
Polymorphism and mutation databases Cosmic; 1890454
Cosmic; 2015225
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number21