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Cellosaurus PC-9/R (CVCL_S750)

[Text version]
Cell line name PC-9/R
Synonyms PC-9R; PC-9/ER; PC-9ER
Accession CVCL_S750
Resource Identification Initiative To cite this cell line use: PC-9/R (RRID:CVCL_S750)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:114785; Erlotinib.
Omics: Transcriptome analysis by RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified; Note=Acquired during resistance selection process (PubMed=22773810).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line

PubMed=21734175; DOI=10.1126/scitranslmed.3002356
Chmielecki J., Foo J., Oxnard G.R., Hutchinson K., Ohashi K., Somwar R., Wang L., Amato K.R., Arcila M.E., Sos M.L., Socci N.D., Viale A.J., de Stanchina E., Ginsberg M.S., Thomas R.K., Kris M.G., Inoue A., Ladanyi M., Miller V.A., Michor F., Pao W.
Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling.
Sci. Transl. Med. 3:90ra59.1-90ra59.10(2011)

PubMed=22773810; DOI=10.1073/pnas.1203530109
Ohashi K., Sequist L.V., Arcila M.E., Moran T., Chmielecki J., Lin Y.-L., Pan Y.-M., Wang L., de Stanchina E., Shien K., Aoe K., Toyooka S., Kiura K., Fernandez-Cuesta L., Fidias P., Yang J.C.-H., Miller V.A., Riely G.J., Kris M.G., Engelman J.A., Vnencak-Jones C.L., Dias-Santagata D., Ladanyi M., Pao W.
Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Proc. Natl. Acad. Sci. U.S.A. 109:E2127-E2133(2012)

PubMed=23733853; DOI=10.1101/gr.152322.112
Jia P.-L., Jin H.-L., Meador C.B., Xia J.-F., Ohashi K., Liu L., Pirazzoli V., Dahlman K.B., Politi K., Michor F., Zhao Z.-M., Pao W.
Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.
Genome Res. 23:1434-1445(2013)

Cell line databases/resources cancercelllines; CVCL_S750
Encyclopedic resources Wikidata; Q54938502
Polymorphism and mutation databases Cosmic; 1890454
Cosmic; 2015225
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number18