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Cellosaurus PC-9/ER3 (CVCL_D726)

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Cell line name PC-9/ER3
Synonyms PC-9-ER3
Accession CVCL_D726
Resource Identification Initiative To cite this cell line use: PC-9/ER3 (RRID:CVCL_D726)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=22712764; DOI=10.1111/j.1349-7006.2012.02363.x; PMCID=PMC7659254
Daijiro Harada, Nagio Takigawa, Nobuaki Ochi, Takashi Ninomiya, Masayuki Yasugi, Toshio Kubo, Hiromasa Takeda, Eiki Ichihara, Kadoaki Ohashi, Saburo Takata, Mitsune Tanimoto, Katsuyuki Kiura;
JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation.
Cancer Sci. 103:1795-1802(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D726
Encyclopedic resources Wikidata; Q54938491
Polymorphism and mutation databases Cosmic; 1745415
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number20