Cellosaurus logo
expasy logo

Cellosaurus PC-9/IR (CVCL_DP47)

[Text version]
Cell line name PC-9/IR
Synonyms PC-9-IR; PC9-IR; PC9/IR; PC9IR; PC9/gef
Accession CVCL_DP47
Resource Identification Initiative To cite this cell line use: PC-9/IR (RRID:CVCL_DP47)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Omics: Proteomics; PTM; Phosphorylation.
Omics: Proteomics; Subcellular; Membrane.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=26202522; DOI=10.1021/acs.jproteome.5b00477; PMCID=PMC4761227
Reta Birhanu Kitata, Baby Rorielyn T. Dimayacyac-Esleta, Wai-Kok Choong, Chia-Feng Tsai, Tai-Du Lin, Chih-Chiang Tsou, Shao-Hsing Weng, Yi-Ju Chen, Pan-Chyr Yang, Susan D. Arco, Alexey I. Nesvizhskii ...Show all 13 authors... , Ting-Yi Sung, Yu-Ju Chen; Show fewer authors
Mining missing membrane proteins by high-pH reverse-phase stagetip fractionation and multiple reaction monitoring mass spectrometry.
J. Proteome Res. 14:3658-3669(2015)

PubMed=26554430; DOI=10.1021/acs.analchem.5b03639
Baby Rorielyn T. Dimayacyac-Esleta, Chia-Feng Tsai, Reta Birhanu Kitata, Pei-Yi Lin, Wai-Kok Choong, Tai-Du Lin, Yi-Ting Wang, Shao-Hsing Weng, Pan-Chyr Yang, Susan D. Arco, Ting-Yi Sung, Yu-Ju Chen;
Rapid high-pH reverse phase stagetip for sensitive small-scale membrane proteomic profiling.
Anal. Chem. 87:12016-12023(2015)

PubMed=28290473; DOI=10.1038/srep44021; PMCID=PMC5349541
Yi-Ting Wang, Szu-Hua Pan, Chia-Feng Tsai, Ting-Chun Kuo, Yuan-Ling Hsu, Hsin-Yung Yen, Wai-Kok Choong, Hsin-Yi Wu, Yen-Chen Liao, Tse-Ming Hong, Ting-Yi Sung ...Show all 13 authors... , Pan-Chyr Yang, Yu-Ju Chen; Show fewer authors
Phosphoproteomics reveals HMGA1, a CK2 substrate, as a drug-resistant target in non-small cell lung cancer.
Sci. Rep. 7:44021-44021(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DP47
Encyclopedic resources Wikidata; Q54938501
Proteomic databases PRIDE; PXD001548
PRIDE; PXD002224
Entry history
Entry creation13-Jul-2016
Last entry update10-Apr-2025
Version number17