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Cellosaurus PC-9/ZD (CVCL_V337)

[Text version]
Cell line name PC-9/ZD
Synonyms PC9 ZD
Accession CVCL_V337
Resource Identification Initiative To cite this cell line use: PC-9/ZD (RRID:CVCL_V337)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Omics: Transcriptomics; Microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=15761868; DOI=10.1002/ijc.20985
Fumiaki Koizumi, Tatsu Shimoyama, Fumiko Taguchi, Nagahiro Saijo, Kazuto Nishio;
Establishment of a human non-small cell lung cancer cell line resistant to gefitinib.
Int. J. Cancer 116:36-44(2005)

Cross-references
Cell line databases/resources cancercelllines; CVCL_V337
Encyclopedic resources Wikidata; Q54938509
Gene expression databases GEO; GSM1374824
Polymorphism and mutation databases Cosmic; 911754
Entry history
Entry creation16-Apr-2014
Last entry update10-Apr-2025
Version number20