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Cellosaurus PC-9/S2 (CVCL_T016)

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Cell line name PC-9/S2
Synonyms PC-9S2
Accession CVCL_T016
Resource Identification Initiative To cite this cell line use: PC-9/S2 (RRID:CVCL_T016)
Comments Population: Chinese; Han and Japanese.
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=23733853; DOI=10.1101/gr.152322.112; PMCID=PMC3759720
Pei-Lin Jia, Hai-Ling Jin, Catherine Belle Meador, Jun-Feng Xia, Kadoaki Ohashi, Lin Liu, Valentina Pirazzoli, Kimberly Brown Dahlman, Katerina Politi, Franziska Michor, Zhong-Ming Zhao, William Pao;
Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.
Genome Res. 23:1434-1445(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_T016
Encyclopedic resources Wikidata; Q54938503
Polymorphism and mutation databases Cosmic; 2015226
Entry history
Entry creation03-Feb-2014
Last entry update10-Apr-2025
Version number20