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Cellosaurus PC-9/GR (CVCL_E7RA)

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Cell line name PC-9/GR
Accession CVCL_E7RA
Resource Identification Initiative To cite this cell line use: PC-9/GR (RRID:CVCL_E7RA)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=39080187; DOI=10.1007/s12094-024-03621-2
Shu-Jun Wu, Ying Liu, Xi Wang, Yan-Bei Ren, Xiang-Hong Li, Huan Wang;
PSIP1 promotes gefitinib resistance in lung adenocarcinoma by inducing the expression of WASF3 and its downstream ITGB3/AKT signaling.
Clin. Transl. Oncol. 27:507-517(2025)

Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1