Cellosaurus logo
expasy logo

Cellosaurus PC-9/ER1 (CVCL_D778)

[Text][XML][JSON]
Cell line name PC-9/ER1
Synonyms PC-9-ER1; PC9-ER1
Accession CVCL_D778
Resource Identification Initiative To cite this cell line use: PC-9/ER1 (RRID:CVCL_D778)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_114785; Erlotinib.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=22815900; DOI=10.1371/journal.pone.0041017; PMCID=PMC3398867
Keisuke Tabara, Rina Kanda, Kahori Sonoda, Takuya Kubo, Yuichi Murakami, Akihiko Kawahara, Koichi Azuma, Hideyuki Abe, Masayoshi Kage, Aki Yoshinaga, Tomoko Tahira ...Show all 17 authors... , Kenshi Hayashi, Tokuzo Arao, Kazuto Nishio, Rafael Rosell, Michihiko Kuwano, Mayumi Ono; Show fewer authors
Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells.
PLoS ONE 7:e41017.1-e41017.16(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_D778
Encyclopedic resources Wikidata; Q54938489
Polymorphism and mutation databases Cosmic; 1731371
Entry history
Entry creation22-Oct-2012
Last entry update19-Dec-2024
Version number21