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Cellosaurus PC-9/GR6 (CVCL_DI32)

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Cell line name PC-9/GR6
Synonyms PC-9 GR6
Accession CVCL_DI32
Resource Identification Initiative To cite this cell line use: PC-9/GR6 (RRID:CVCL_DI32)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified; Note=Responsible for gefitinib resistance (PubMed=20118985).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=20118985; DOI=10.1038/onc.2009.526; PMCID=PMC2859699
Dalia Ercan, Kreshnik Zejnullahu, Kimio Yonesaka, Yun Xiao, Marzia Capelletti, Andrew Rogers, Eugene Lifshits, Alison Brown, Charles Lee, James Gail Christensen, David Joseph Kwiatkowski ...Show all 13 authors... , Jeffrey Adam Engelman, Pasi Antero Janne; Show fewer authors
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor.
Oncogene 29:2346-2356(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DI32
Encyclopedic resources Wikidata; Q54938499
Gene expression databases GEO; GSM481166
Polymorphism and mutation databases Progenetix; CVCL_DI32
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number15