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Cellosaurus PC-9/GR2 (CVCL_DI29)

[Text version]
Cell line name PC-9/GR2
Synonyms PC-9 GR2; PC9-GR2
Accession CVCL_DI29
Resource Identification Initiative To cite this cell line use: PC-9/GR2 (RRID:CVCL_DI29)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Omics: Transcriptomics; RNAseq.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified; Note=Responsible for gefitinib resistance (PubMed=20118985).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=20118985; DOI=10.1038/onc.2009.526; PMCID=PMC2859699
Dalia Ercan, Kreshnik Zejnullahu, Kimio Yonesaka, Yun Xiao, Marzia Capelletti, Andrew Rogers, Eugene Lifshits, Alison Brown, Charles Lee, James Gail Christensen, David Joseph Kwiatkowski ...Show all 13 authors... , Jeffrey Adam Engelman, Pasi Antero Janne; Show fewer authors
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor.
Oncogene 29:2346-2356(2010)

PubMed=26828195; DOI=10.1038/nm.4040; PMCID=PMC4900892
Aaron Nathaniel Hata, Matthew J. Niederst, Hannah Linn Archibald, Maria Gomez-Caraballo, Faria Madeena Siddiqui, Hillary E. Mulvey, Yosef E. Maruvka, Fei Ji, Hyo-eun Carrie Bhang, Viveksagar Krishnamurthy Radhakrishna, Giulia Siravegna ...Show all 30 authors... , Hai-Chuan Hu, Sana Raoof, Elizabeth L. Lockerman, Anuj Kalsy, Dana Lee, Celina L. Keating, David A. Ruddy, Leah J. Damon, Adam S. Crystal, Carlotta Costa, Zofia Piotrowska, Alberto Bardelli, Anthony John Iafrate, Ruslan I. Sadreyev, Frank Stegmeier, Gad Getz, Lecia VanDam Sequist, Anthony C. Faber, Jeffrey Adam Engelman; Show fewer authors
Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition.
Nat. Med. 22:262-269(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DI29
Encyclopedic resources Wikidata; Q54938495
Gene expression databases GEO; GSM481162
GEO; GSM1960268
GEO; GSM1960269
GEO; GSM1960270
GEO; GSM1960271
Polymorphism and mutation databases Progenetix; CVCL_DI29
Entry history
Entry creation13-Jul-2016
Last entry update10-Apr-2025
Version number16