ID   PC-9/GR2
AC   CVCL_DI29
SY   PC-9 GR2; PC9-GR2
DR   cancercelllines; CVCL_DI29
DR   GEO; GSM481162
DR   GEO; GSM1960268
DR   GEO; GSM1960269
DR   GEO; GSM1960270
DR   GEO; GSM1960271
DR   Progenetix; CVCL_DI29
DR   Wikidata; Q54938495
RX   PubMed=20118985;
RX   PubMed=26828195;
CC   Population: Chinese; Han and Japanese.
CC   Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified; Note=Responsible for gefitinib resistance (PubMed=20118985).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B260 ! PC-9
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 13-07-16; Last updated: 10-04-25; Version: 16
//
RX   PubMed=20118985; DOI=10.1038/onc.2009.526; PMCID=PMC2859699;
RA   Ercan, Dalia
RA   Zejnullahu, Kreshnik
RA   Yonesaka, Kimio
RA   Xiao, Yun
RA   Capelletti, Marzia
RA   Rogers, Andrew
RA   Lifshits, Eugene
RA   Brown, Alison
RA   Lee, Charles
RA   Christensen, James Gail
RA   Kwiatkowski, David Joseph
RA   Engelman, Jeffrey Adam
RA   Janne, Pasi Antero
RT   "Amplification of EGFR T790M causes resistance to an irreversible EGFR
RT   inhibitor.";
RL   Oncogene 29:2346-2356(2010).
//
RX   PubMed=26828195; DOI=10.1038/nm.4040; PMCID=PMC4900892;
RA   Hata, Aaron Nathaniel
RA   Niederst, Matthew J.
RA   Archibald, Hannah Linn
RA   Gomez-Caraballo, Maria
RA   Siddiqui, Faria Madeena
RA   Mulvey, Hillary E.
RA   Maruvka, Yosef E.
RA   Ji, Fei
RA   Bhang, Hyo-eun Carrie
RA   Krishnamurthy Radhakrishna, Viveksagar
RA   Siravegna, Giulia
RA   Hu, Hai-Chuan
RA   Raoof, Sana
RA   Lockerman, Elizabeth L.
RA   Kalsy, Anuj
RA   Lee, Dana
RA   Keating, Celina L.
RA   Ruddy, David A.
RA   Damon, Leah J.
RA   Crystal, Adam S.
RA   Costa, Carlotta
RA   Piotrowska, Zofia
RA   Bardelli, Alberto
RA   Iafrate, Anthony John
RA   Sadreyev, Ruslan I.
RA   Stegmeier, Frank
RA   Getz, Gad
RA   Sequist, Lecia VanDam
RA   Faber, Anthony C.
RA   Engelman, Jeffrey Adam
RT   "Tumor cells can follow distinct evolutionary paths to become
RT   resistant to epidermal growth factor receptor inhibition.";
RL   Nat. Med. 22:262-269(2016).
//