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Cellosaurus RPC-9 (CVCL_B263)

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Cell line name RPC-9
Synonyms RPC9
Accession CVCL_B263
Resource Identification Initiative To cite this cell line use: RPC-9 (RRID:CVCL_B263)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=17699786; DOI=10.1158/0008-5472.CAN-07-0681
Atsuko Ogino, Hiroyuki Kitao, Seiki Hirano, Akiko Uchida, Masamichi Ishiai, Toshiyuki Kozuki, Nagio Takigawa, Minoru Takata, Katsuyuki Kiura, Mitsune Tanimoto;
Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non small cell lung cancer cell line.
Cancer Res. 67:7807-7814(2007)

Cross-references
Cell line databases/resources cancercelllines; CVCL_B263
Encyclopedic resources Wikidata; Q54951132
Polymorphism and mutation databases Cosmic; 1083085
Entry history
Entry creation06-Jun-2012
Last entry update19-Dec-2024
Version number20