• Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  
• Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Thr790Met (c.2369C>T); ClinVar=VCV000016613; Zygosity=Unspecified; Note=Responsible for gefitinib resistance (PubMed=20118985).
  
• Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
  

PubMed=20118985; DOI=10.1038/onc.2009.526; PMCID=PMC2859699
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Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor.
Oncogene 29:2346-2356(2010)

PubMed=22961667; DOI=10.1158/2159-8290.CD-12-0103; PMCID=PMC3477553
Dalia Ercan, Chun-Xiao Xu, Masahiko Yanagita, Calixte S. Monast, Christine A. Pratilas, Joan Montero, Mohit Butaney, Takeshi Shimamura, Lynette Marie Sholl, Elena V. Ivanova, Madhavi Tadi ...Show all 23 authors... , Andrew Rogers, Claire Repellin, Marzia Capelletti, Ophelia Maertens, Eva M. Goetz, Anthony George Letai, Levi Alexander Garraway, Matthew J. Lazzara, Neal Rosen, Nathanael S. Gray, Kwok-Kin Wong, Pasi Antero Janne; Show fewer authors
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.
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