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Cellosaurus PC-9/GR4 (CVCL_DH34)

[Text version]
Cell line name PC-9/GR4
Synonyms PC-9 GR4; PC9GR4; GR4
Accession CVCL_DH34
Resource Identification Initiative To cite this cell line use: PC-9/GR4 (RRID:CVCL_DH34)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_B260 (PC-9)
CVCL_DI33 (PC-9/DR1)CVCL_DI34 (PC-9/DR2)CVCL_DI35 (PC-9/DR3)
CVCL_DI36 (PC-9/DR4)CVCL_DI37 (PC-9/DR5)CVCL_DI38 (PC-9/DR6)
CVCL_DG30 (PC-9/WZR09)CVCL_DG31 (PC-9/WZR10)CVCL_DG32 (PC-9/WZR11)
CVCL_DG33 (PC-9/WZR12)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line

PubMed=20118985; DOI=10.1038/onc.2009.526
Ercan D., Zejnullahu K., Yonesaka K., Xiao Y., Capelletti M., Rogers A., Lifshits E., Brown A., Lee C., Christensen J.G., Kwiatkowski D.J., Engelman J.A., Janne P.A.
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor.
Oncogene 29:2346-2356(2010)

PubMed=22961667; DOI=10.1158/2159-8290.CD-12-0103
Ercan D., Xu C.-X., Yanagita M., Monast C.S., Pratilas C.A., Montero J., Butaney M., Shimamura T., Sholl L.M., Ivanova E.V., Tadi M., Rogers A., Repellin C., Capelletti M., Maertens O., Goetz E.M., Letai A.G., Garraway L.A., Lazzara M.J., Rosen N., Gray N.S., Wong K.-K., Janne P.A.
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.
Cancer Discov. 2:934-947(2012)

Cell line databases/resources cancercelllines; CVCL_DH34
Encyclopedic resources Wikidata; Q54938497
Gene expression databases GEO; GSM925738
GEO; GSM481164
Polymorphism and mutation databases Progenetix; CVCL_DH34
Entry history
Entry creation13-Jul-2016
Last entry update05-Oct-2023
Version number13