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Cellosaurus PC-9/WZR09 (CVCL_DG30)

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Cell line name PC-9/WZR09
Synonyms WZR09; WZR9
Accession CVCL_DG30
Resource Identification Initiative To cite this cell line use: PC-9/WZR09 (RRID:CVCL_DG30)
Comments Population: Chinese; Han and Japanese.
Selected for resistance to: ChEBI; CHEBI_49668; Gefitinib (ZD1839; Iressa).
Selected for resistance to: ChEBI; CHEBI_61400; WZ4002 (N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide).
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
  • Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DH34 (PC-9/GR4)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=22961667; DOI=10.1158/2159-8290.CD-12-0103; PMCID=PMC3477553
Dalia Ercan, Chun-Xiao Xu, Masahiko Yanagita, Calixte S. Monast, Christine A. Pratilas, Joan Montero, Mohit Butaney, Takeshi Shimamura, Lynette Marie Sholl, Elena V. Ivanova, Madhavi Tadi ...Show all 23 authors... , Andrew Rogers, Claire Repellin, Marzia Capelletti, Ophelia Maertens, Eva M. Goetz, Anthony George Letai, Levi Alexander Garraway, Matthew J. Lazzara, Neal Rosen, Nathanael S. Gray, Kwok-Kin Wong, Pasi Antero Janne; Show fewer authors
Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.
Cancer Discov. 2:934-947(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DG30
Encyclopedic resources Wikidata; Q54938505
Gene expression databases GEO; GSM925739
Polymorphism and mutation databases Progenetix; CVCL_DG30
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number15