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Cellosaurus ZR-75-1 (CVCL_0588)

[Text version]
Cell line name ZR-75-1
Synonyms Zr-75-1; ZR751; ZR75-1; ZR75.1; ZR75_1
Accession CVCL_0588
Resource Identification Initiative To cite this cell line use: ZR-75-1 (RRID:CVCL_0588)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: ICBP43 breast cancer cell line panel.
Part of: JFCR45 cancer cell line panel.
Part of: JWGray breast cancer cell line panel.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Population: Caucasian.
Doubling time: 80 hours (Note=At 40th passage) (PubMed=688225); 79 hours (PubMed=24389870); ~54 hours (PBCF); 70.09 hours (JWGray panel).
Omics: Genomics; ChIP-seq; H2BK120ub.
Omics: Genomics; ChIP-seq; H3K23ac.
Omics: Genomics; ChIP-seq; H3K27ac.
Omics: Genomics; ChIP-seq; H3K27me3.
Omics: Genomics; ChIP-seq; H3K36me3.
Omics: Genomics; ChIP-seq; H3K4me1.
Omics: Genomics; ChIP-seq; H3K4me3.
Omics: Genomics; ChIP-seq; H3K79me2.
Omics: Genomics; ChIP-seq; H3K9ac.
Omics: Genomics; ChIP-seq; H3K9me3.
Omics: Genomics; ChIP-seq; H4K8ac.
Omics: Genomics; Whole exome sequencing.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; Glycoproteome.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; miRNA profiling; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Omics: Variations; SNP array analysis.
Anecdotal: Used in a study utilising the fruit fly's olfactory system to detect cancer cells (PubMed=24389870).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (DepMap=ACH-000097).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (PubMed=19593635; DepMap=ACH-000097).
HLA typing Source: PubMed=25960936
Class I
HLA-AA*24/11,11
HLA-BB*35:01
HLA-CC*04:01,04:01
Class II
HLA-DQDQB1*05:01,05:01
HLA-DRDRB1*01:01,13:03

Source: PubMed=26589293
Class I
HLA-AA*11:01,24:02
HLA-BB*35:01,35:01
HLA-CC*04:01,04:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North1.23
East Asian, South0
South Asian0.14
European, North65.96
European, South32.67
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E1F8 (Ubigene ZR-75-1 CEBPA KO)CVCL_E1F9 (Ubigene ZR-75-1 CEBPB KO)CVCL_E1FA (Ubigene ZR-75-1 LDHA KO)
CVCL_E1FB (Ubigene ZR-75-1 RNF20 KO)CVCL_E1FC (Ubigene ZR-75-1 SATB1 KO)CVCL_E1FD (Ubigene ZR-75-1 SLC25A38 KO)
CVCL_2814 (YMB-1)CVCL_E4WR (ZR-75-1 AKT1 pool B)CVCL_E4WS (ZR-75-1 AKT2 pool B)
CVCL_E4WT (ZR-75-1 BCAR1 clone 4A12)CVCL_E4WU (ZR-75-1 BCAR3 clone B3-10)CVCL_E4WV (ZR-75-1 BCAR4 clone 2A)
CVCL_E4WW (ZR-75-1 BCAR4 clone 2B)CVCL_A1FN (ZR-75-1 GDC-0941-resistant)CVCL_E4WX (ZR-75-1 GRB7 clone 3)
CVCL_E4WY (ZR-75-1 GRB7 clone 4)CVCL_E4WZ (ZR-75-1 HRAS pool A)CVCL_E4X0 (ZR-75-1 HRAS pool B)
CVCL_E4X1 (ZR-75-1 HygroR clone ZH2D2)CVCL_E4X2 (ZR-75-1 HygroR clone ZH3D7)CVCL_E4KZ (ZR-75-1 IX-10)
CVCL_E4L0 (ZR-75-1 IX-23)CVCL_E4L1 (ZR-75-1 IX-6)CVCL_E4X3 (ZR-75-1 PDGFRA clone 21)
CVCL_E4X4 (ZR-75-1 PDGFRA clone 30)CVCL_E4X5 (ZR-75-1 PDGFRB clone 4147)CVCL_E4X6 (ZR-75-1 RAF1 clone T2)
CVCL_RA95 (ZR-75-1 shPARG)CVCL_YJ29 (ZR-75-1 shWDR12-4)CVCL_A4AL (ZR-75-1 Tam1)
CVCL_A4AM (ZR-75-1 Tam2)CVCL_E4L2 (ZR-75-1 VIII-11)CVCL_E4L3 (ZR-75-1 VIII-12)
CVCL_E4L4 (ZR-75-1 VIII-16)CVCL_E4L5 (ZR-75-1 VIII-17)CVCL_E4L6 (ZR-75-1 VIII-18)
CVCL_E4L7 (ZR-75-1 VIII-20)CVCL_E4L8 (ZR-75-1 VIII-21)CVCL_E4L9 (ZR-75-1 VIII-22)
CVCL_E4LA (ZR-75-1 VIII-24)CVCL_E4LB (ZR-75-1 VIII-5)CVCL_E4LC (ZR-75-1 X-10)
CVCL_E4LD (ZR-75-1 X-3)CVCL_E4LE (ZR-75-1 X-4)CVCL_E4LF (ZR-75-1 X-5)
CVCL_E4LG (ZR-75-1 X-6)CVCL_E4LH (ZR-75-1 X-7)CVCL_E4LI (ZR-75-1 X-8)
CVCL_E4LJ (ZR-75-1 XI-13)CVCL_E4LK (ZR-75-1 XI-14)CVCL_E4LL (ZR-75-1 XI-15)
CVCL_E4LM (ZR-75-1 XI-16)CVCL_E4LN (ZR-75-1 XI-17)CVCL_E4LP (ZR-75-1 XI-18)
CVCL_E4LQ (ZR-75-1 XI-19)CVCL_E4LR (ZR-75-1 XI-20)CVCL_E4LS (ZR-75-1 XI-21)
CVCL_E4LT (ZR-75-1 XI-22)CVCL_E4LU (ZR-75-1 XI-27)CVCL_E4LV (ZR-75-1 XI-30)
CVCL_E4LW (ZR-75-1 XI-31)CVCL_E4LX (ZR-75-1 XI-32)CVCL_E4LY (ZR-75-1 XI-33)
CVCL_E4LZ (ZR-75-1 XI-35)CVCL_E4M0 (ZR-75-1 XI-36)CVCL_E4M1 (ZR-75-1 XI-38)
CVCL_E4M2 (ZR-75-1 XI-39)CVCL_E4M3 (ZR-75-1 XI-41)CVCL_E4M4 (ZR-75-1 XII-1)
CVCL_E4M5 (ZR-75-1 XII-10)CVCL_E4M6 (ZR-75-1 XII-11)CVCL_E4M7 (ZR-75-1 XII-12)
CVCL_E4M8 (ZR-75-1 XII-13)CVCL_E4M9 (ZR-75-1 XII-14)CVCL_E4MA (ZR-75-1 XII-2)
CVCL_E4MB (ZR-75-1 XII-4)CVCL_E4MC (ZR-75-1 XII-6)CVCL_E4MD (ZR-75-1 XII-7)
CVCL_E4ME (ZR-75-1 XII-8)CVCL_E4MF (ZR-75-1 XII-9)CVCL_E4MG (ZR-75-1 XIV-10)
CVCL_E4MH (ZR-75-1 XIV-15)CVCL_E4MI (ZR-75-1 XIV-16)CVCL_E4MJ (ZR-75-1 XIV-17)
CVCL_E4MK (ZR-75-1 XIV-2)CVCL_E4ML (ZR-75-1 XIV-22)CVCL_E4MM (ZR-75-1 XIV-26)
CVCL_E4MN (ZR-75-1 XIV-31)CVCL_E4MP (ZR-75-1 XIV-32)CVCL_E4MQ (ZR-75-1 XIV-34)
CVCL_E4MR (ZR-75-1 XIV-36)CVCL_E4MS (ZR-75-1 XIV-37)CVCL_E4MT (ZR-75-1 XIV-39)
CVCL_E4MU (ZR-75-1 XIV-42)CVCL_E4MV (ZR-75-1 XIV-43)CVCL_E4MW (ZR-75-1 XIV-5)
CVCL_E4MX (ZR-75-1 XIV-50)CVCL_E4MY (ZR-75-1 XIV-51)CVCL_E4MZ (ZR-75-1 XIV-55)
CVCL_E4N0 (ZR-75-1 XIV-57)CVCL_E4N1 (ZR-75-1 XIV-6)CVCL_E4N2 (ZR-75-1 XIV-9)
CVCL_E4N3 (ZR-75-1 ZN11B)CVCL_E4N4 (ZR-75-1 ZN1E)CVCL_E4N5 (ZR-75-1 ZN2A)
CVCL_E4N6 (ZR-75-1 ZN3B)CVCL_E4N7 (ZR-75-1 ZN5B)CVCL_UJ20 (ZR-75-1-Dox)
CVCL_JY90 (ZR-75-1/GFP)CVCL_5613 (ZR-75-9a1)CVCL_5614 (ZR-75-B)
CVCL_D3W9 (ZR/HERc 1A)CVCL_D3WA (ZR/HERc 1D)CVCL_D3WB (ZR/HERc 1E)
CVCL_D3WC (ZR/HERc 1F)CVCL_D3WD (ZR/HERc 1G)CVCL_D3WE (ZR/HERc 2B)
CVCL_4Y42 (ZR75-1 25DOCR)CVCL_4Y44 (ZR75-1 25PACR)CVCL_4Y43 (ZR75-1 50DOCR)
CVCL_4Y45 (ZR75-1 50PACR)CVCL_YX86 (ZR75-LTED)CVCL_YX82 (ZR75.1 A3)
CVCL_IW49 (ZR75T)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0006011/4901; ATCC=CRL-1500; CCRID; CLS=300163; ECACC=87012601; KCLB=21500; PubMed=25877200; PubMed=28889351; Technion Genomics Center

Markers:
AmelogeninX
CSF1PO10,11
D1S165614.3,16.3
D2S44111,15
D2S133816,25
D3S135815,16
D5S81813
D7S82010 (KCLB=21500)
10,11 (AddexBio=C0006011/4901; ATCC=CRL-1500; CCRID; CLS=300163; ECACC=87012601; PubMed=25877200; PubMed=28889351; Technion Genomics Center)
D8S117911,13
D10S124816
D12S39121
D13S3179
D16S53911
D18S5113,14
D19S43313,14
D21S1131
D22S104515
FGA20,22
Penta D14
Penta E7,14
TH017,9.3
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Web pages Info; ATCC; -; https://www.atcc.org/en/support/technical-support/faqs/morphology-of-atcc-crl-1500
Info; LINCS; ICBP43; https://lincs.hms.harvard.edu/resources/reagents/icbp43/
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Pawefish; -; https://www.cellosaurus.org/pawefish/BreastCellLineDescriptions/zr-75-1.htm
Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
Info; Synapse; PS-ON; https://www.synapse.org/#!Synapse:syn31544564
Info; Wikipedia; -; https://en.wikipedia.org/wiki/ZR-75-1
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/breast-cancer-xenograft/zr-75-1-xenograft-model/
Publications

PubMed=688225
Linda W. Engel, Nathaniel A. Young, Tommie Sue Tralka, Marc E. Lippman, Stephen James O'Brien, Mary Jo Joyce;
Establishment and characterization of three new continuous cell lines derived from human breast carcinomas.
Cancer Res. 38:3352-3364(1978)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Michael Jules Mattes, Carlos Cordon-Cardo, John L. Lewis Jr., Lloyd John Old, Kenneth Oliver Lloyd;
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=1911442; DOI=10.1016/0960-0760(91)90248-4
Martin James Wild, Philip Spencer Rudland, David J. Back;
Metabolism of the oral contraceptive steroids ethynylestradiol and norgestimate by normal (Huma 7) and malignant (MCF-7 and ZR-75-1) human breast cells in culture.
J. Steroid Biochem. Mol. Biol. 39:535-543(1991)

PubMed=7902062
Manuel de la Torre, Xiao-Yong Hao, Rolf Larsson, Peter Nygren, Takashi Tsuruo, Bengt Mannervik, Jonas Bergh;
Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases.
Anticancer Res. 13:1425-1430(1993)

DOI=10.1016/B978-0-12-333530-2.50009-5
Albert Leibovitz;
Cell lines from human breast.
(In book chapter) Atlas of human tumor cell lines; Hay, Robert J. & Park, Jae-Gahb & Gazdar, Adi F. (eds.); pp.161-184; Academic Press; New York; USA (1994)

PubMed=10862037; DOI=10.1002/1098-2264(200007)28:3<308::AID-GCC9>3.0.CO;2-B
Soili Kytola, Jaana Rummukainen, Ann Nordgren, Ritva Karhu, Filip Farnebo, Jorma J. Isola, Catharina Larsson;
Chromosomal alterations in 15 breast cancer cell lines by comparative genomic hybridization and spectral karyotyping.
Genes Chromosomes Cancer 28:308-317(2000)

PubMed=10969801
Farahnaz Forozan, Eija H. Mahlamaki, Outi Monni, Yi-Dong Chen, Robin Veldman, Yuan Jiang, Gerald C. Gooden, Stephen P. Ethier, Anne H. Kallioniemi, Olli-Pekka Kallioniemi;
Comparative genomic hybridization analysis of 38 breast cancer cell lines: a basis for interpreting complementary DNA microarray data.
Cancer Res. 60:4519-4525(2000)

PubMed=11044355; DOI=10.1054/bjoc.2000.1458; PMCID=PMC2408781
Jeffrey M. Davidson, Kylie Louise Gorringe, Suet-Feung Chin, Beatrice Orsetti, C. Besret, Celine Courtay-Cahen, Ian Roberts, Charles Theillet, Carlos Caldas, Paul A.W. Edwards;
Molecular cytogenetic analysis of breast cancer cell lines.
Br. J. Cancer 83:1309-1317(2000)

PubMed=11343771; DOI=10.1016/S0165-4608(00)00387-3
Jaana Rummukainen, Soili Kytola, Ritva Karhu, Filip Farnebo, Catharina Larsson, Jorma J. Isola;
Aberrations of chromosome 8 in 16 breast cancer cell lines by comparative genomic hybridization, fluorescence in situ hybridization, and spectral karyotyping.
Cancer Genet. Cytogenet. 126:1-7(2001)

PubMed=12353263; DOI=10.1002/gcc.10107
Cornel Popovici, Celine Basset, Francois Bertucci, Beatrice Orsetti, Jose Adelaide, Marie-Joelle Mozziconacci, Nathalie Conte, Anne Murati, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Stephen P. Ethier ...Show all 15 authors... , Marina Lafage-Pochitaloff, Charles Theillet, Daniel Birnbaum, Max Chaffanet; Show fewer authors
Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene.
Genes Chromosomes Cancer 35:204-218(2002)

PubMed=12800145; DOI=10.1002/gcc.10218
Jose Adelaide, Huai-En Huang, Anne Murati, Amber E. Alsop, Beatrice Orsetti, Marie-Joelle Mozziconacci, Cornel Popovici, Christophe Ginestier, Anne Letessier, Celine Basset, Celine Courtay-Cahen ...Show all 16 authors... , Jocelyne Jacquemier, Charles Theillet, Daniel Birnbaum, Paul A.W. Edwards, Max Chaffanet; Show fewer authors
A recurrent chromosome translocation breakpoint in breast and pancreatic cancer cell lines targets the neuregulin/NRG1 gene.
Genes Chromosomes Cancer 37:333-345(2003)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Kylie Louise Gorringe, Suet-Feung Chin, Paul D.P. Pharoah, Joanne M. Staines, Carla Oliveira, Paul A.W. Edwards, Carlos Caldas;
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Noriyuki Nakatsu, Yoko Yoshida, Kanami Yamazaki, Tomoki Nakamura, Shingo Dan, Yasuhisa Fukui, Takao Yamori;
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853
Fons Elstrodt, Antoinette Hollestelle, Jord H.A. Nagel, Michael Gorin, Marijke Wasielewski, Ans M.W. van den Ouweland, Sofia Diana Merajver, Stephen P. Ethier, Mieke Schutte;
BRCA1 mutation analysis of 41 human breast cancer cell lines reveals three new deleterious mutants.
Cancer Res. 66:41-45(2006)

PubMed=16541312; DOI=10.1007/s10549-006-9186-z
Marijke Wasielewski, Fons Elstrodt, Jan G.M. Klijn, Els M.J.J. Berns, Mieke Schutte;
Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines.
Breast Cancer Res. Treat. 99:97-101(2006)

PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521
Richard M. Neve, Koei Chin, Jane Fridlyand, Jennifer Yeh, Frederick L. Baehner, Tea Fevr, Laura Clark, Nora Bayani, Jean-Philippe Coppe, Frances Tong, Terry Speed ...Show all 27 authors... , Paul T. Spellman, Sandy DeVries, Anna Lapuk, Nick J. Wang, Wen-Lin Kuo, Jackie L. Stilwell, Daniel Pinkel, Donna G. Albertson, Frederic M. Waldman, Frank McCormick, Robert Brent Dickson, Michael D. Johnson, Marc E. Lippman, Stephen P. Ethier, Adi F. Gazdar, Joe W. Gray; Show fewer authors
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes.
Cancer Cell 10:515-527(2006)

PubMed=17334996; DOI=10.1002/gcc.20438
Goran Jonsson, Johan Staaf, Eleonor Olsson, Markus Heidenblad, Johan Vallon-Christersson, Kazutoyo Osoegawa, Pieter J. de Jong, Stina M. Oredsson, Markus Ringner, Mattias Hoglund, Ake Borg;
High-resolution genomic profiles of breast cancer cell lines assessed by tiling BAC array comparative genomic hybridization.
Genes Chromosomes Cancer 46:543-558(2007)

PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004; PMCID=PMC2391005
Paraic A. Kenny, Genee Y. Lee, Connie A. Myers, Richard M. Neve, Jeremy R. Semeiks, Paul T. Spellman, Kristina Lorenz, Eva H. Lee, Mary Helen Barcellos-Hoff, Ole William Petersen, Joe W. Gray, Mina J. Bissell;
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.
Mol. Oncol. 1:84-96(2007)

PubMed=19582160; DOI=10.1371/journal.pone.0006146; PMCID=PMC2702084
Jessica Kao, Keyan Salari, Melanie Bocanegra, Yoon-La Choi, Luc Girard, Jeet Gandhi, Kevin A. Kwei, Tina Hernandez-Boussard, Pei Wang, Adi F. Gazdar, John D. Minna, Jonathan R. Pollack;
Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.
PLoS ONE 4:e6146.1-e6146.16(2009)

PubMed=19727395; DOI=10.1371/journal.pone.0006888; PMCID=PMC2731225
Raymond Couric Wadlow, Ben S. Wittner, S. Aidan Finley, Henry Bergquist, Rabi Upadhyay, Stephen P. Finn, Massimo Loda, Umar Mahmood, Sridhar Ramaswamy;
Systems-level modeling of cancer-fibroblast interaction.
PLoS ONE 4:e6888.1-e6888.10(2009)

DOI=10.25904/1912/1434
Brian J. Morrison;
Breast cancer stem cells: tumourspheres and implications for therapy.
Thesis PhD (2010); Griffith University; Brisbane; Australia

PubMed=19593635; DOI=10.1007/s10549-009-0460-8
Antoinette Hollestelle, Jord H.A. Nagel, Marcel Smid, Suzanne Lam, Fons Elstrodt, Marijke Wasielewski, Ser Sue Ng, Pim J. French, Justine K. Peeters, Marieke J. Rozendaal, Muhammad Riaz ...Show all 26 authors... , Daphne G. Koopman, Timo L.M. ten Hagen, Bertie H.C.G.M. de Leeuw, Ellen C. Zwarthoff, Amina F.A.S. Teunisse, Peter J. van der Spek, Jan G.M. Klijn, Winand N.M. Dinjens, Stephen P. Ethier, Hans Cornelius Clevers, Aart G. Jochemsen, Michael A. den Bakker, John A. Foekens, John W.M. Martens, Mieke Schutte; Show fewer authors
Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines.
Breast Cancer Res. Treat. 121:53-64(2010)

PubMed=20070913; DOI=10.1186/1471-2407-10-15; PMCID=PMC2836299
Katumi Tsuji, Shigeto Kawauchi, Soichiro Saito, Tomoko Furuya, Kenzo Ikemoto, Motonao Nakao, Shigeru Yamamoto, Masaaki Oka, Takashi Hirano, Kohsuke Sasaki;
Breast cancer cell lines carry cell line-specific genomic alterations that are distinct from aberrations in breast cancer tissues: comparison of the CGH profiles between cancer cell lines and primary cancer tissues.
BMC Cancer 10:15.1-15.10(2010)

PubMed=21378333
Christopher H.J. Ford, Maie Al-Bader, Bushra Al-Ayadhi, Issam Francis;
Reassessment of estrogen receptor expression in human breast cancer cell lines.
Anticancer Res. 31:521-527(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Richard Marcotte, Kevin R. Brown, Fernando Jose Suarez Saiz, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice Lie-Yong Koh, Dewald van Dyk ...Show all 28 authors... , Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel, Jason Moffat; Show fewer authors
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661
Muhammad Riaz, Marijn T.M. van Jaarsveld, Antoinette Hollestelle, Wendy J.C. Prager-van der Smissen, Anouk A.J. Heine, Antonius W.M. Boersma, Jing-Jing Liu, Jean C.A. Helmijr, Bahar Ozturk, Marcel Smid, Erik A.C. Wiemer ...Show all 13 authors... , John A. Foekens, John W.M. Martens; Show fewer authors
miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs.
Breast Cancer Res. 15:R33.1-R33.17(2013)

PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310
Luika A. Timmerman, Thomas Holton, Mariia Yuneva, Raymond J. Louie, Merce Padro, Anneleen Daemen, Min Hu, Denise A. Chan, Stephen P. Ethier, Laura J. van 't Veer, Kornelia Polyak ...Show all 13 authors... , Frank McCormick, Joe W. Gray; Show fewer authors
Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target.
Cancer Cell 24:450-465(2013)

PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776
Aleix Prat, Olga Karginova, Joel S. Parker, Cheng Fan, Xia-Ping He, Lisa M. Bixby, J. Chuck Harrell, Erick Roman, Barbara Adamo, Melissa A. Troester, Charles M. Perou;
Characterization of cell lines derived from breast cancers and normal mammary tissues for the study of the intrinsic molecular subtypes.
Breast Cancer Res. Treat. 142:237-255(2013)

PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590
Anneleen Daemen, Obi L. Griffith, Laura M. Heiser, Nicholas J. Wang, Oana M. Enache, Zachary Sanborn, Francois Pepin, Steffen Durinck, James E. Korkola, Malachi Griffith, Joe S. Hur ...Show all 27 authors... , Nam Huh, Jongsuk Chung, Leslie Cope, Mary Jo Fackler, Christopher Benedict Umbricht, Saraswati Sukumar, Pankaj Seth, Vikas P. Sukhatme, Lakshmi R. Jakkula, Yi-Ling Lu, Gordon B. Mills, Raymond J. Cho, Eric A. Collisson, Laura J. van 't Veer, Paul T. Spellman, Joe W. Gray; Show fewer authors
Modeling precision treatment of breast cancer.
Genome Biol. 14:R110.1-R110.14(2013)

PubMed=24389870; DOI=10.1038/srep03576; PMCID=PMC3880960
Martin Strauch, Alja Ludke, Daniel Munch, Thomas Laudes, Cosmas Giovanni Galizia, Eugenio Martinelli, Luca Lavra, Roberto Paolesse, Alessandra Ulivieri, Alexandro Catini, Rosamaria Capuano, Corrado Di Natale;
More than apples and oranges -- detecting cancer with a fruit fly's antenna.
Sci. Rep. 4:3576.1-3576.9(2014)

PubMed=25238572; DOI=10.1021/pr500727h
Michael Groessl, Astrid Slany, Andrea Bileck, Kerstin Gloessmann, Dominique Kreutz, Walter Jaeger, Georg Pfeiler, Christopher Gerner;
Proteome profiling of breast cancer biopsies reveals a wound healing signature of cancer-associated fibroblasts.
J. Proteome Res. 13:4773-4782(2014)

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981
Sebastian Boegel, Martin Lower, Thomas Bukur, Ugur Sahin, John C. Castle;
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
OncoImmunology 3:e954893.1-e954893.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25699542; DOI=10.15252/msb.20145664; PMCID=PMC4358660
Markus K. Muellner, Barbara Mair, Yasir Ibrahim, Claudia Kerzendorfer, Hannelore Lechtermann, Claudia Trefzer, Freya Klepsch, Andre C. Muller, Ernestine Leitner, Sabine Macho-Maschler, Giulio Superti-Furga ...Show all 18 authors... , Keiryn L. Bennett, Jose Baselga, Uwe Rix, Stefan Kubicek, Jacques Colinge, Violeta Serra, Sebastian M.B. Nijman; Show fewer authors
Targeting a cell state common to triple-negative breast cancers.
Mol. Syst. Biol. 11:789-789(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26759240; DOI=10.1158/0008-5472.CAN-15-2201
Yoshito Nakanishi, Kimberly Walter, Jill M. Spoerke, Carol O'Brien, Ling Y. Huw, Garret M. Hampton, Mark R. Lackner;
Activating mutations in PIK3CB confer resistance to PI3K inhibition and define a novel oncogenic role for p110beta.
Cancer Res. 76:1193-1203(2016)

PubMed=27378269; DOI=10.1186/s12885-016-2452-5; PMCID=PMC4932681
Sara Kangaspeska, Susanne Hultsch, Alok Jaiswal, Henrik Edgren, John Patrick Mpindi, Samuli Eldfors, Oscar Bruck, Tero Aittokallio, Olli-Pekka Kallioniemi;
Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer.
BMC Cancer 16:378.1-378.17(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28287265; DOI=10.1021/acs.jproteome.6b00470; PMCID=PMC5557415
Ten-Yang Yen, Spencer Bowen, Roger Yen, Alexandra Piryatinska, Bruce A. Macher, Leslie C. Timpe;
Glycoproteins in claudin-low breast cancer cell lines have a unique expression profile.
J. Proteome Res. 16:1391-1400(2017)

PubMed=28889351; DOI=10.1007/s10549-017-4496-x
Jodi M. Saunus, Chanel E. Smart, Jamie R. Kutasovic, Rebecca L. Johnston, Priyakshi Kalita-de Croft, Mariska Miranda, Esdy N. Rozali, Ana Cristina Vargas, Lynne E. Reid, Eva Lorsy, Sibylle Cocciardi ...Show all 23 authors... , Tatjana Seidens, Amy Ellen McCart Reed, Andrew J. Dalley, Leesa F. Wockner, Julie Johnson, Debina Sarkar, Marjan E. Askarian-Amiri, Peter T. Simpson, Kum Kum Khanna, Georgia Chenevix-Trench, Fares Al-Ejeh, Sunil R. Lakhani; Show fewer authors
Multidimensional phenotyping of breast cancer cell lines to guide preclinical research.
Breast Cancer Res. Treat. 167:289-301(2018)

PubMed=29273624; DOI=10.1101/gr.226019.117; PMCID=PMC5793780
Hector L. Franco, Anusha Nagari, Venkat S. Malladi, Wen-Qian Li, Yuan-Xin Xi, Dana Richardson, Kendra L. Allton, Kaori Tanaka, Jing Li, Shino Murakami, Khandan Keyomarsi ...Show all 17 authors... , Mark T. Bedford, Xiao-Bing Shi, Wei Li, Michelle C. Barton, Sharon Yoder Roth Dent, W. Lee Kraus; Show fewer authors
Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis.
Genome Res. 28:159-170(2018)

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Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
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Nature 569:503-508(2019)

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Quantitative proteomics of the Cancer Cell Line Encyclopedia.
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Cross-references
Cell line collections (Providers) AddexBio; C0006011/4901
ATCC; CRL-1500
BCRC; 60055
CancerTools; 154547
CLS; 300163
ECACC; 87012601
IBRC; C10099
ICLC; HTL99006
IZSLER; BS TCL 75
KCB; KCB 2010136YJ
KCLB; 21500
RCB; RCB1906 - Discontinued
TKG; TKG 0189
Cell line databases/resources CLO; CLO_0009727
MCCL; MCC:0000494
CLDB; cl4817
CLDB; cl4818
CLDB; cl4819
CLDB; cl4820
CLDB; cl4821
CLDB; cl4946
cancercelllines; CVCL_0588
CCRID; 1101HUM-PUMC000090
CCRID; 3101HUMTCHu126
Cell_Model_Passport; SIDM00314
DepMap; ACH-000097
IPD-IMGT/HLA; 12334
LINCS_HMS; 50574
LINCS_LDP; LCL-1321
SLKBase; 3633
Anatomy/cell type resources BTO; BTO_0003136
Biological sample resources BioSample; SAMN01821608
BioSample; SAMN03471337
BioSample; SAMN05292440
BioSample; SAMN10988134
CRISP screens repositories BioGRID_ORCS_Cell_line; 339
Chemistry resources ChEMBL-Cells; CHEMBL3307615
ChEMBL-Targets; CHEMBL614393
PharmacoDB; ZR751_1689_2019
PubChem_Cell_line; CVCL_0588
Encyclopedic resources Wikidata; Q54996114
Experimental variables resources EFO; EFO_0001262
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-TABM-157
ArrayExpress; E-TABM-244
GEO; GSM73744
GEO; GSM115120
GEO; GSM155214
GEO; GSM217613
GEO; GSM274660
GEO; GSM344360
GEO; GSM344410
GEO; GSM350508
GEO; GSM378142
GEO; GSM383804
GEO; GSM383805
GEO; GSM383806
GEO; GSM388216
GEO; GSM421897
GEO; GSM481332
GEO; GSM783956
GEO; GSM844725
GEO; GSM845400
GEO; GSM847449
GEO; GSM847509
GEO; GSM887750
GEO; GSM888845
GEO; GSM1008921
GEO; GSM1053721
GEO; GSM1172908
GEO; GSM1173004
GEO; GSM1215256
GEO; GSM1238137
GEO; GSM1374993
GEO; GSM1374994
GEO; GSM1374995
GEO; GSM1401648
GEO; GSM1556182
GEO; GSM1556183
GEO; GSM1556184
GEO; GSM1556185
GEO; GSM1556186
GEO; GSM1664567
GEO; GSM2258740
GEO; GSM2258741
GEO; GSM2258742
GEO; GSM2258743
GEO; GSM2258744
GEO; GSM2258745
GEO; GSM2258746
GEO; GSM2258747
GEO; GSM2258748
GEO; GSM2258749
GEO; GSM2258750
GEO; GSM2258751
GEO; GSM2258752
GEO; GSM2258753
GEO; GSM2258754
GEO; GSM2258755
GEO; GSM2258756
GEO; GSM2258757
GEO; GSM2258956
GEO; GSM2258957
GEO; GSM2258958
Polymorphism and mutation databases Cosmic; 687503
Cosmic; 755295
Cosmic; 871152
Cosmic; 877452
Cosmic; 894094
Cosmic; 904398
Cosmic; 934532
Cosmic; 944296
Cosmic; 979717
Cosmic; 991333
Cosmic; 997927
Cosmic; 1010919
Cosmic; 1044205
Cosmic; 1046930
Cosmic; 1047720
Cosmic; 1136344
Cosmic; 1152530
Cosmic; 1175836
Cosmic; 1287904
Cosmic; 1289421
Cosmic; 1309006
Cosmic; 1326279
Cosmic; 1523772
Cosmic; 1524343
Cosmic; 1571792
Cosmic; 1603229
Cosmic; 1609464
Cosmic; 2165028
Cosmic; 2301536
Cosmic; 2318372
Cosmic; 2361354
Cosmic; 2668279
Cosmic; 2750519
Cosmic; 2787556
IARC_TP53; 21111
LiGeA; CCLE_225
Progenetix; CVCL_0588
Proteomic databases PRIDE; PXD001327
PRIDE; PXD005390
Sequence databases EGA; EGAS00001000610
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number47