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Cellosaurus ZR-75-1 BCAR4 clone 2A (CVCL_E4WV)

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Cell line name ZR-75-1 BCAR4 clone 2A
Synonyms ZR-BCAR4 2A
Accession CVCL_E4WV
Resource Identification Initiative To cite this cell line use: ZR-75-1 BCAR4 clone 2A (RRID:CVCL_E4WV)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:22170; BCAR4.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=16778085; DOI=10.1158/1541-7786.MCR-05-0156
Danielle Meijer, Ton van Agthoven, Peter T. Bosma, Kees Nooter, Lambert C.J. Dorssers;
Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells.
Mol. Cancer Res. 4:379-386(2006)

Cross-references
Cell line collections (Providers) CancerTools; 154625
Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number3