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Cellosaurus ZR75-LTED (CVCL_YX86)

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Cell line name ZR75-LTED
Synonyms ZR75 LTED; ZR75-Long Term Estrogen-Deprived
Accession CVCL_YX86
Resource Identification Initiative To cite this cell line use: ZR75-LTED (RRID:CVCL_YX86)
Comments Population: Caucasian.
Characteristics: Derived from parent cell line by long-term culture in the presence of RPMI 1640 medium containing 10% dextran charcoal stripped serum (DCC) (PubMed=26116361).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=26116361; DOI=10.1158/1535-7163.MCT-15-0143
Ricardo Ribas, Sunil Pancholi, Stephanie K. Guest, Elisabetta Marangoni, Qiong Gao, Aurelie Thuleau, Nikiana Simigdala, Urszula M. Polanska, Hayley Campbell, Aradhana Rani, Gianmaria Liccardi ...Show all 15 authors... , Stephen R.D. Johnston, Barry Robert Davies, Mitch Dowsett, Lesley-Ann Martin; Show fewer authors
AKT antagonist AZD5363 influences estrogen receptor function in endocrine-resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo.
Mol. Cancer Ther. 14:2035-2048(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_YX86
Encyclopedic resources Wikidata; Q98136617
Entry history
Entry creation12-Mar-2020
Last entry update10-Apr-2025
Version number10