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Cellosaurus ZR-75-1 shWDR12-4 (CVCL_YJ29)

[Text version]
Cell line name ZR-75-1 shWDR12-4
Accession CVCL_YJ29
Resource Identification Initiative To cite this cell line use: ZR-75-1 shWDR12-4 (RRID:CVCL_YJ29)
Comments Population: Caucasian.
Doubling time: 23-37 hours (CelloPub=CLPUB00550).
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:14098; WDR12.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): CelloPub=CLPUB00550

Markers:
AmelogeninX
CSF1PO10,11
D5S81813
D7S82010,11
D13S3179
D16S53911
TH017,9.3
TPOX8
vWA16,18

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Publications

CLPUB00550
Sophie Benhamron;
Validating WDR12 as a potential drug target in triple negative breast cancer.
Thesis MSc (2019); University of Toronto; Toronto; Canada

Cross-references
Cell line databases/resources cancercelllines; CVCL_YJ29
Encyclopedic resources Wikidata; Q98136608
Entry history
Entry creation19-Dec-2019
Last entry update14-Aug-2025
Version number10