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Cellosaurus ZR-75-1 Tam2 (CVCL_A4AM)

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Cell line name ZR-75-1 Tam2
Accession CVCL_A4AM
Resource Identification Initiative To cite this cell line use: ZR-75-1 Tam2 (RRID:CVCL_A4AM)
Comments Population: Caucasian.
Doubling time: ~1 week (ATCC=CRL-3439).
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Omics: Genomics; Whole exome sequencing.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=27378269; DOI=10.1186/s12885-016-2452-5; PMCID=PMC4932681
Sara Kangaspeska, Susanne Hultsch, Alok Jaiswal, Henrik Edgren, John Patrick Mpindi, Samuli Eldfors, Oscar Bruck, Tero Aittokallio, Olli-Pekka Kallioniemi;
Systematic drug screening reveals specific vulnerabilities and co-resistance patterns in endocrine-resistant breast cancer.
BMC Cancer 16:378.1-378.17(2016)

Cross-references
Cell line collections (Providers) ATCC; CRL-3439
Cell line databases/resources cancercelllines; CVCL_A4AM
Encyclopedic resources Wikidata; Q105511866
Entry history
Entry creation12-Jan-2021
Last entry update10-Apr-2025
Version number9