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Cellosaurus ZR-75-1 shPARG (CVCL_RA95)

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Cell line name ZR-75-1 shPARG
Synonyms shPARG ZR-75-1
Accession CVCL_RA95
Resource Identification Initiative To cite this cell line use: ZR-75-1 shPARG (RRID:CVCL_RA95)
Comments Population: Caucasian.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:8605; PARG.
Omics: Proteomics; PTM; Poly-ADP-ribosylation.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106; PMCID=PMC5728415
Yuan-Li Zhen, Ya-Jie Zhang, Yong-Hao Yu;
A cell-line-specific atlas of PARP-mediated protein Asp/Glu-ADP-ribosylation in breast cancer.
Cell Rep. 21:2326-2337(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RA95
Encyclopedic resources Wikidata; Q54996115
Entry history
Entry creation05-Mar-2018
Last entry update14-Aug-2025
Version number12