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Cellosaurus ZR-75-1 BCAR1 clone 4A12 (CVCL_E4WT)

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Cell line name ZR-75-1 BCAR1 clone 4A12
Synonyms ZR-75-1 BCAR1 [4A12]
Accession CVCL_E4WT
Resource Identification Initiative To cite this cell line use: ZR-75-1 BCAR1 clone 4A12 (RRID:CVCL_E4WT)
Comments Population: Caucasian.
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:971; BCAR1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=10639512; DOI=10.1093/jnci/92.2.112
Arend Brinkman, Silvia van der Flier, Elisabeth M. Kok, Lambert C.J. Dorssers;
BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
J. Natl. Cancer Inst. 92:112-120(2000)

Cross-references
Cell line collections (Providers) CancerTools; 154621
Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number3