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Cellosaurus ZR/HERc 1D (CVCL_D3WA)

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Cell line name ZR/HERc 1D
Synonyms ZR-HERc 1D
Accession CVCL_D3WA
Resource Identification Initiative To cite this cell line use: ZR/HERc 1D (RRID:CVCL_D3WA)
Comments Population: Caucasian.
Characteristics: Expresses EGFR under the control of HSV-1 TK promoter (PubMed=1516065).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3236; EGFR.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=1516065
Ton van Agthoven, Thecla L.A. van Agthoven, Henk Portengen, John A. Foekens, Lambert C.J. Dorssers;
Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-1 human breast cancer cells.
Cancer Res. 52:5082-5088(1992)

Cross-references
Encyclopedic resources Wikidata; Q127384782
Entry history
Entry creation30-Jan-2024
Last entry update14-Aug-2025
Version number4