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Cellosaurus ZR-75-1 VIII-11 (CVCL_E4L2)

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Cell line name ZR-75-1 VIII-11
Synonyms ZR-75-1 [VIII-11]
Accession CVCL_E4L2
Resource Identification Initiative To cite this cell line use: ZR-75-1 VIII-11 (RRID:CVCL_E4L2)
Comments Population: Caucasian.
Characteristics: Infected with an amphotropic defective murine retrovirus. Retroviral insertion was used in order to identify genes responsible for estrogen-independence and thus tamoxifen resistant (PubMed=8413311; PubMed=18351453).
Characteristics: Genes likely to be responsible to resistance in this cell line are CAPN8 and ZFAND6 (PubMed=18351453).
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=8413311; DOI=10.1210/mend.7.7.8413311
Lambert C.J. Dorssers, Ton van Agthoven, Anita Dekker, Thecla L.A. van Agthoven, Elisabeth M. Kok;
Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site.
Mol. Endocrinol. 7:870-878(1993)

PubMed=18351453; DOI=10.1007/s10549-008-9969-5
Ton van Agthoven, Jos Willibrordus Veldscholte, Marcel Smid, Thecla L.A. van Agthoven, Lilian Vreede, Marieke Broertjes, Ingrid de Vries, Danielle de Jong, Roya Sarwari, Lambert C.J. Dorssers;
Functional identification of genes causing estrogen independence of human breast cancer cells.
Breast Cancer Res. Treat. 114:23-30(2009)

Cross-references
Cell line collections (Providers) CancerTools; 154552
Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number3