Cellosaurus logo
expasy logo

Cellosaurus ZR-75-1-Dox (CVCL_UJ20)

[Text][XML][JSON]
Cell line name ZR-75-1-Dox
Synonyms Zr-75-1-Dox
Accession CVCL_UJ20
Resource Identification Initiative To cite this cell line use: ZR-75-1-Dox (RRID:CVCL_UJ20)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: Proteomics; PTM; Poly-ADP-ribosylation.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=7902062
Manuel de la Torre, Xiao-Yong Hao, Rolf Larsson, Peter Nygren, Takashi Tsuruo, Bengt Mannervik, Jonas Bergh;
Characterization of four doxorubicin adapted human breast cancer cell lines with respect to chemotherapeutic drug sensitivity, drug resistance associated membrane proteins and glutathione transferases.
Anticancer Res. 13:1425-1430(1993)

Cross-references
Cell line databases/resources cancercelllines; CVCL_UJ20
Encyclopedic resources Wikidata; Q98136613
Entry history
Entry creation25-Feb-2019
Last entry update10-Apr-2025
Version number10