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Cellosaurus ZR75-1 25DOCR (CVCL_4Y42)

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Cell line name ZR75-1 25DOCR
Accession CVCL_4Y42
Resource Identification Initiative To cite this cell line use: ZR75-1 25DOCR (RRID:CVCL_4Y42)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_4672; Docetaxel anhydrous (Taxotere).
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=25312014; DOI=10.1186/1471-2407-14-762; PMCID=PMC4203938
Juliet Kenicer, Melanie Spears, Nicola Lyttle, Karen J. Taylor, Linda Liao, Carrie A. Cunningham, Maryou B. Lambros, Alan Mackay, Cindy Yao, Jorge Sergio Reis-Filho, John M.S. Bartlett;
Molecular characterisation of isogenic taxane resistant cell lines identify novel drivers of drug resistance.
BMC Cancer 14:762.1-762.10(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_4Y42
Encyclopedic resources Wikidata; Q54996129
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number12