ID   ZR75-1 25DOCR
AC   CVCL_4Y42
DR   cancercelllines; CVCL_4Y42
DR   Wikidata; Q54996129
RX   PubMed=25312014;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_4672; Docetaxel anhydrous (Taxotere).
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0588 ! ZR-75-1
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 14-12-15; Last updated: 19-12-24; Version: 12
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RX   PubMed=25312014; DOI=10.1186/1471-2407-14-762; PMCID=PMC4203938;
RA   Kenicer, Juliet
RA   Spears, Melanie
RA   Lyttle, Nicola
RA   Taylor, Karen J.
RA   Liao, Linda
RA   Cunningham, Carrie A.
RA   Lambros, Maryou B.
RA   Mackay, Alan
RA   Yao, Cindy
RA   Reis-Filho, Jorge Sergio
RA   Bartlett, John M.S.
RT   "Molecular characterisation of isogenic taxane resistant cell lines
RT   identify novel drivers of drug resistance.";
RL   BMC Cancer 14:762.1-762.10(2014).
//