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Cellosaurus ZR-75-1 PDGFRB clone 4147 (CVCL_E4X5)

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Cell line name ZR-75-1 PDGFRB clone 4147
Synonyms ZR-PDGFRB (4147)
Accession CVCL_E4X5
Resource Identification Initiative To cite this cell line use: ZR-75-1 PDGFRB clone 4147 (RRID:CVCL_E4X5)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_41774; Tamoxifen.
Genetic integration: Method=Transduction; Gene=HGNC; HGNC:5173; HRAS.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
Publications

PubMed=19966015; DOI=10.1677/ERC-09-0062
Ton van Agthoven, Anieta M. Sieuwerts, Danielle Meijer, Marion E. Meijer-van Gelder, Thecla L.A. van Agthoven, Roya Sarwari, Stefan Sleijfer, John A. Foekens, Lambert C.J. Dorssers;
Selective recruitment of breast cancer anti-estrogen resistance genes and relevance for breast cancer progression and tamoxifen therapy response.
Endocr. Relat. Cancer 17:215-230(2010)

Cross-references
Cell line collections (Providers) CancerTools; 154634
Entry history
Entry creation19-Dec-2024
Last entry update14-Aug-2025
Version number3